FASEB Summer Conference on Phospholipases

描述（由申请人提供）：本申请寻求FASEB磷脂酶夏季研究会议的部分资金，该会议将于2004年7月17日至7月22日在格鲁吉亚松山的卡拉威花园举行。 这将是第七届ASB会议。 所要求的资金将专门用于支付初级调查员的登记和差旅费，他们将出席会议并作为特邀报告、简短演讲或海报介绍其工作。 这个成功的和既定的会议的广泛目标是提供一个形式的审查和讨论的结构，功能和调节的磷脂酶是酶，催化水解的酯和磷酸二酯键在膜磷脂的最新研究。 这类广泛表达的酶的成员通过产生生物活性脂质和脂质衍生产物在细胞调节的许多方面发挥核心作用。 磷脂酶A产生脂肪酸和溶血磷脂。 这些酶启动包括溶血磷脂酸和花生四烯酸的类花生酸代谢物的受体活性脂质的产生，并且在癌症和包括哮喘的炎性疾病中具有明确的作用。磷脂酶C响应于细胞表面受体的激动剂活化而产生磷酸肌醇和甘油二酯第二信使，磷脂酶D从磷脂酰胆碱产生磷脂酸，其调节与细胞生长、存活、运动性和囊泡运输的控制偶联的信号传导途径。 会议还包括关于合成和降解鞘脂的酶的会谈，鞘脂在细胞应激反应和凋亡中发挥作用，以及通过质谱分析脂质结构的会议。 这次会议汇集了科学家，他们对这些酶有着共同的兴趣，这些酶在不同的学科中工作，包括生物物理学，结构，细胞和分子生物学。 会议有一个强有力的记录，包括从一开始就介绍和建立调查，并提供了一个有效的论坛，促进合作和新的进展，在该领域。 该主题领域得到了NIH的大力支持，有400多个活跃的项目由NIH各主要研究所提供的资金支持。 在过去的10年里，该领域每年产生约2000篇同行评审的研究出版物。 本提案所要求的资金将为支持这次会议作出宝贵贡献。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Research Conference on Phospholipases to be held from July 17- July 22 2004 in Callaway Gardens, Pine Mountain, Georgia. This will be the seventh ASB conference on this subject. The funds requested will be used exclusively to support the registration and travel expenses of junior investigators who will be attending the conference and presenting their work as invited presentations, short talks or posters. The broad goal of this successful and established conference is to provide a form for review and discussion of recent research on the structure, function and regulation of phospholipases which are enzymes that catalyze the hydrolysis of ester and phosphodiester bonds in membrane phospholipids. Members of this widely expressed class of enzymes play central roles in many aspects of cell regulation by producing bioactive lipids and lipid-derived products. Phospholipases A generate fatty acids and lysophospholipids. These enzymes initiate production of receptor-active lipids including lysophosphatidic acid and the eicosanoid metabolites of arachidonic acid and have well established roles in cancer and inflammatory diseases including asthma. Phospholipases C produce inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors and Phospholipases D generate phosphatidic acid from phosphatidylcholine which regulates signaling pathways coupled to control of cell growth, survival, motility and vesicular transport. The conference also includes talks on enzymes that synthesise and degrade sphingolipids that have roles in cellular stress responses and apoptosis as well as a session on analysis of lipid structures by mass spectrometry. This conference brings together scientists with a shared interest in these enzymes that are working in diverse disciplines including biophysics, structural, cell and molecular biology. The conference has a strong record of including presentations from beginning and established investigators and provides an effective forum for promoting collaborations and new advances in the field. The subject area is one that receives considerable support from the NIH with over 400 active projects sustained by funds provided by each of the major NIH institutes. For the past 10 years this field has generated about 2000 peer reviewed research publications each year. The funds requested in this proposal will make an invaluable contribution to the support of this conference.