International Conference-Structural Mechanisms in Muscle

描述（由申请人提供）： 这次为期两天的国际会议将于2004年5月20日和21日在伦敦国王学院新亨特楼举行，会议的目的是突出肌肉中蛋白质结构和功能的最新进展。肌肉是人体中最丰富的组织，其正常功能在健康的许多方面都是必不可少的。肌肉功能的退化是衰老、心脏病、动脉粥样硬化和诸如肌肉萎缩症之类的毁灭性遗传疾病的突出症状。 我们目前对肌肉以及肌肉的收缩和调节机制的理解，大部分都源于50年前提出的滑丝假说。在《自然》杂志上发表的两篇论文中，Jean Hanson博士是四位合著者之一。她后来成为兰德尔研究所（现在的兰德尔中心，坐落在新亨特的房子）主任。这次会议庆祝她的科学贡献和研究，已经从她的工作。它特别关注丝状蛋白质，肌动蛋白和肌球蛋白，以及它们的相关蛋白质，她在1973年过早去世之前的职业生涯中做出了如此显着和开创性的贡献。因此，会议的一个主要目的是吸引和提高年轻科学家，特别是女性科学家对肌肉研究的兴趣和承诺。会议将包括国际知名科学家和青年科学家的演讲以及海报展示。科学主题将集中在涉及肌肉中粗丝和细丝蛋白质的结构机制上。 肌肉研究的一个显著成果是，研究肌肉结构、机制和发育的技术已经渗透到涉及细胞外和细胞内运动的生物学研究中。方法包括单分子纳米技术，同步辐射和疾病的遗传基础，所有这些都将在会议讨论的主题中举例说明。

DESCRIPTION (provided by applicant): The goal of this two-day international conference to be held on May 20th and 21st 2004 in New Hunt's House, King's College London is to highlight recent advances in the structure and function of proteins in muscle. Muscle is the most abundant tissue in the human body and its proper function is essential in many aspects of health. Deterioration of muscle function is a prominent symptom in ageing, heart disease, atherosclerosis and such devastating genetic diseases such as muscular dystrophy. Much of our current understanding of muscle and of contractile and regulatory mechanisms of muscle stems from the sliding filament hypothesis that was formulated fifty years ago. One of the four co-authors in the two Nature papers that marked the formulation was Dr Jean Hanson. She went on to become Director of the Randall Institute (now the Randall Centre, sited in New Hunt's House). This conference celebrates her scientific contributions and the research that has followed from her work. It focuses in particular on the filamentous proteins, actin and myosin, and their associated proteins to which she made such notable and seminal contributions during her career before her premature death in 1973. A principal aim therefore of the conference is to attract and enhance the interest and commitment of young, and especially women, scientists to muscle research. The meeting will be a combination of talks by internationally recognized scientists and young scientists, and of poster presentations. Scientific themes will concentrate on structural mechanisms involving proteins of the thick and thin filaments in muscle. A remarkable outgrowth of research in muscle is the way in which techniques developed to investigate its structure, mechanisms and development have pervaded so much of biological studies involving extra and intracellular movement. Approaches include single-molecule nanotechnology, synchrotron radiation and the genetic basis of disease, all of which will be exemplified in the topics discussed at the conference.