Frontiers in Structural Biology

描述（由申请人提供）：结构生物学家正在以惊人的速度破译复杂生物过程的机制。x射线晶体学提供了复杂分子组合的原子分辨率结构，核磁共振波谱学为溶液和膜中越来越大的生物分子提供了结构和动力学信息。荧光光谱学是产生在体外和体内工作的大分子机器的图像。这种丰富的结构信息是由生物大分子结构和动力学的计算分析的显著改进所补充的。所有这些新信息的整合需要一种跨学科的方法，利用广泛的生化和生物物理工具来探测分子功能，同时保持生物学重要问题的中心地位。Keystone会议将汇集对这些问题感兴趣的结构生物学家，这些问题对基础生物学和药物发现过程都具有重要意义。

DESCRIPTION (provided by applicant): Structural biologists are deciphering the mechanisms of complex biological processes at a breathtaking pace. X-ray crystallography is providing atomic-resolution structures of complex molecular assemblies, and NMR spectroscopy is providing structural and dynamical information for ever-larger biomolecules in solution and in membranes. Fluorescence spectroscopy is yielding images of macromolecular machines at work both in vitro and in vivo. This wealth of structural information is complemented by dramatic improvements in the computational analysis of the structure and dynamics of biological macromolecules. The integration of all this new information requires an inter-disciplinary approach that utilizes a wide range of biochemical and biophysical tools to probe molecular function, while keeping the biologically important questions at center stage. The Keystone Meeting will bring together structural biologists interested in these issues, which have important implications both for fundamental biology and for the process of drug discovery.