Cell Cycle and Development

描述（由申请人提供）：本次Keystone研讨会的目标是汇集科学家，利用不同的模型系统研究正常发育过程中细胞周期控制的机制。尽管许多定期会议的重点是发育或细胞周期控制，但很少有人专门讨论这两个传统上分开的领域的接口。然而，最近对不同模式生物的研究，包括小鼠、果蝇、秀丽隐杆线虫和拟南芥，已经开始揭示许多令人兴奋的见解，即细胞周期控制机制是如何由发育程序控制的。由于细胞周期控制和发育调节系统都是高度保守的，因此连接这两个生物过程的机制和策略也有望是进化保守的。因此，研究不同生物的科学家可以从彼此身上学到很多东西。本次研讨会将讨论以下问题：细胞周期控制装置的哪些组成部分在胚胎发生和器官发生过程中受到调节？细胞周期调控基因如何整合不同的发育线索？什么机制协调细胞生长与细胞周期进程？虽然研究的目的是关注正常的发育而不是疾病，但了解正常的增殖控制对于充分理解癌症中发生的不受管制的增殖的基础或伤口愈合和再生所需的增殖再激活是至关重要的。这种跨系统、以主题为重点的会议在促进新方法在系统之间的转移、突出不同模型的适当使用以及定义一般范例和无知领域方面应该是无价的。为期四天的八场会议将包括来自各种受邀演讲者和从提交的摘要中挑选的演讲者的演讲。下午是用来做海报展示和非正式互动的。由于这种类型的大型会议之前从未举行过，我们认为这次研讨会将是一个独特的培训和交流场所，为主要研究人员以及参与细胞周期控制研究的博士后和研究生。

DESCRIPTION (provided by applicant): The goal of this Keystone Symposium is to bring together scientists studying the mechanisms of cell cycle control during normal development, using diverse model systems. Although many regular meetings are focused on either development or cell cycle control, exceedingly few have specifically addressed the interface of these two traditionally separate fields. Nevertheless, recent research in divergent model organisms including mice, Drosphila, C. elegans, and Arabidopsis, has begun to reveal many exciting insights into how the cell cycle control machinery is governed by developmental programs. Since both cell cycle control and developmental regulatory systems are highly conserved, the mechanisms and strategies connecting these two biological processes are also expected to be evolutionary conserved. Hence scientists working on very different organisms can learn tremendously from one another. This Symposium will address the following questions: Which components of the cell cycle control apparatus are regulated during embryogenesis and organogenesis? How are diverse developmental cues integrated by cell cycle regulatory genes? What mechanisms coordinate cell growth with cell cycle progression? Although the intent is to focus on normal development rather than disease, an understanding of normal proliferative control will be essential to fully understand the basis of the deregulated proliferation that occurs in cancer, or the proliferative re-activation required for wound healing and regeneration. This cross-system, topic-focused meeting should be invaluable in promoting the transfer of new methodologies between systems, highlighting the appropriate uses of the different models, and defining general paradigms and areas of ignorance. Eight sessions running over four days will consist of talks from a diverse array of invited speakers and speakers selected from submitted abstracts. Afternoons are reserved for poster presentations and informal interactions. Because a large meeting of this type has not been held before, we think this Symposium will be a unique training and networking venue for principal Investigators as well as postdoctorals and graduate students involved in studies of cell cycle control during development.