GRC on Second Messengers & Protein Phosphorylation

描述（由申请人提供）：我们要求部分支持戈登第二信使和蛋白质磷酸化研究会议（GRC）的运作，该会议自70年代初以来每年举行一次。多年来，这个GRC一直是导致几项诺贝尔奖的研究首次发表的场所。该会议每年在新罕布什尔州梅里登的金博尔联合学院举行，该学院为与会者提供了一个熟悉和方便的场所，以促进与会者之间的开放互动。2003年的GRC将于6月8日星期日晚上开始，6月12日星期四晚上结束。会议的重点是调节细胞生长、分化、生存和代谢的信号转导机制。充分了解这些信号机制在科学上和临床上都很重要，因为它们的失效在影响全球数百万人的当代健康问题中起着直接作用，如糖尿病、肥胖、衰老、癌症、心血管疾病、神经退行性疾病和发育障碍。我们鼓励演讲者将生物化学、结构、细胞生物学和基因组学方法结合起来，全面了解与疾病有关的信号机制的分子方面。全体会议发言人已被选中，为会议奠定了基础，并挑战与会者从新的角度思考信号转导。会议将由8个会议组成，每个会议由一名讨论主持人和四名演讲者组成，他们都是从最近做出重要贡献的研究人员中挑选出来的。演讲者中至少有20%是女性或少数群体成员。每个会议的演讲者将发展信号转导中重要范例的结构和功能，并将这些系统与疾病机制和潜在的治疗策略联系起来。联合主席将从申请者中选出135名参与者，包括工业界和学术界的代表、资深科学家、博士后和研究生。将特别努力通过直接邮寄计划招募少数族裔参与者。参加者将被鼓励在每天下午展示新的和有趣的结果的海报。重要的是，会议为年轻的研究人员提供了一个论坛，让他们看到基础科学探究与科学方法应用于设计有效的人类疾病干预措施之间的联系。为了强调这一目标，将选择四份与会议主题相辅相成的海报报告，在主要会议期间进行简短的口头报告。

DESCRIPTION (provided by applicant): We are requesting partial support for operation of the Gordon Research Conference (GRC) on Second Messengers and Protein Phosphorylation, which has been held annually since the early 70's. Over the years this GRC has been the venue where research leading to several Nobel Prizes was first presented. The meeting is held annually at Kimball Union Academy in Meriden, New Hampshire, which provides a familiar and handicapped-accessible venue to promote open interaction among participants. The 2003 iteration of this GRC will begin on Sunday night June 8 and conclude on Thursday evening June 12. The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, aging, cancer, cardiovascular disease, neurodegeneration, and developmental disorders. The speakers are encouraged to integrate biochemical, structural, cell biological and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. The plenary speaker has been selected to set the stage for the conference and to challenge the participants to think about signal transduction from novel perspectives. The conference will consist of 8 sessions, each with a discussion leader and four speakers, selected from investigators who have made important recent contributions. At least 20% of the speakers are women or members of minority groups. Speakers in each session will develop the structure and function of important paradigms in signal transduction and relate these systems to disease mechanisms and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants by a direct mailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, four poster presentations that complement the themes of the meeting will be selected for brief oral presentation during the main sessions.