Meetings on Modeling Human Cancer in Mice

描述（由申请人提供）：结直肠癌是美国癌症死亡的第二大原因。1995年，约有16万结直肠癌新病例，其中6万人死于该疾病。在了解病因和改善这种疾病的治疗方面取得进展的要求之一是发展新的动物模型，在这些模型中可以研究正常组织生物学和癌变的所有阶段。这些工具已经到位，可以为癌症研究准备新的小鼠模型；我们需要的是基础和临床研究人员之间就人类肿瘤的分子生物学、它们的起源和进展以及实验室小鼠的生物学相关性和建模进行对话。为此，Jackson实验室建立了一系列用于研究人类癌症的小鼠模型的年会和合作研讨会，其总体目标是讨论临床前小鼠模型的开发和验证及其在转化性癌症研究中的应用。该系列旨在支持NCI于1998年7月29日发布的“人类癌症小鼠模型联盟”（MMHCC） RFA CA-98-013。第一次会议于1999年10月举行，重点是乳腺癌和在临床前研究中使用小鼠模型。随后的会议强调了在小鼠中建立人类癌症模型的最新进展，重点是结肠直肠癌（2000年）、前列腺癌（2001年）、临床前试验（2002年）和肺癌（2003年）。本申请要求为“在小鼠中模拟人类结直肠癌”系列的第六年提供支持，该系列将于2004年9月30日至10月3日由杰克逊实验室和美国癌症研究协会（AACR）在Bar Harbor俱乐部举行。会议将紧接“小鼠人类结直肠癌建模技术”的研讨会。工作坊的16名学生将被免费邀请参加会议。活跃的研究人员和来自世界各地的学生将有机会分享想法，建立新的合作关系，讨论目前的进展，并规划肠上皮及其肿瘤的生物学分析的未来方向。

DESCRIPTION (provided by applicant): Colorectal cancer is the second leading cause of cancer deaths in the United States. In 1995, there were about 160,000 new cases of colorectal cancers with 60,000 deaths resulting from the disease. One of the requirements for progress in understanding the etiology and improving the treatment of this disease is the development of new animal models in which normal tissue biology and all stages of carcinogenesis can be investigated. The tools are in place to prepare new mouse models for cancer research; what is needed is a dialog between basic and clinical researchers about the molecular biology of human tumors, their initiation and progression with respect to biological correlates and modeling in the laboratory mouse. To this end, The Jackson Laboratory has established a series of annual meetings and companion workshops on mouse models for studying human cancer with the overall goal of discussing the development and validation of preclinical mouse models and their use in translational cancer research. This series was designed to support the "Mouse Models of Human Cancer Consortium" (MMHCC) RFA CA-98-013 released by NCI on July 29, 1998. The first meeting, held in October of 1999, focused on mammary cancer and the use of mouse models in preclinical research. Subsequent meetings highlighting the latest in modeling human cancer in mice focused on colorectal cancer (2000), prostate cancer (2001), preclinical trials (2002) and lung cancer (2003). This application requests support for a sixth year in the series titled "Modeling Human Colorectal Cancer in Mice" to be held at The Bar Harbor Club in Bar Harbor by Jackson Laboratory and The American Association for Cancer Research (AACR) on September 30 - October 3, 2004. The meeting will immediately follow a companion workshop "Techniques for Modeling Human Colorectal Cancer in Mice". Students (16) from the workshop will be invited to attend the meeting free of charge. Active investigators and students from around the world will have an opportunity to share ideas, establish new collaborations, discuss current progress and chart future directions in the biological analysis of the intestinal epithelium and its neoplasms.