Efficacy of Thin HA Coatings Produced by a Novel Process

产品说明：（申请人提供）本项目正在开发新一代牙种植体用磷酸钙涂层，其中优化了薄膜结晶度，以增强生物活性和骨结合。第一阶段检查了最佳结晶度导致更快和更强的器械固定的假设。通过一种新的低温沉积方法制备了30-90%的膜堆叠度，并在小动物模型（大鼠）中进行了评价。发现理想范围为50-70%结晶。与传统的等离子喷涂涂层相比，这些涂层提供了骨-器械整合。 第II阶段计划的目的是进一步评估和证明具有优化结晶度的磷酸钙涂层的优势，如第I阶段所定义。在假体加载前后，将在大型动物（犬）模型中评估早期和长期骨反应。将这种创新技术引入牙科种植体领域的愿望是基于该工艺相对于用于将HA涂层应用于种植体的现有技术的两个主要优点。首先，所施加的涂层的化学组成和结晶度可以在宽的值范围内精确地控制，而不需要沉积后退火。第二，HA涂层可以在低温下沉积为1至5 μ/m厚的薄膜，比使用等离子体喷涂技术施加的涂层薄得多。较薄的涂层可以提供比较厚的等离子体喷涂涂层更高的界面强度和更好的耐受性。

DESCRIPTION: (provided by the applicant) This project is developing a new generation of calcium phosphate coatings for dental implants, in which film crystallinity is optimized for enhanced bioactivity and osseointegration. Phase I examined the hypothesis that optimal crystallinity leads to more rapid and stronger device fixation. Film crystallinities ranging from 30-90% were produced by a novel, low temperature deposition method and evaluated in a small animal model (rat). It was found that the ideal range was between 50-70% crystalline. These coatings provided bone-device integration compared to conventional plasma spray coatings. The purpose of the Phase II program is to further evaluate and demonstrate the advantage of calcium phosphate coatings with optimized crystallinity, as defined in Phase I. Both early and long-term bone response will be assessed in a large animal (canine) model, both prior to and after prosthesis loading. The desire to introduce this innovative technology to the field of dental implantology is based on two primary advantages of the process over existing technology used to apply HA coatings to implants. First, the chemical composition and crystallinity of the applied coating can be precisely controlled over a wide range of values, without the need for post deposition annealing. Second, the HA coatings can be deposited at low temperature as thin films from 1 to 5 mu/m thick, much thinner than coatings applied using plasma spray technology. Thinner coatings can provide a higher interfacial strength and better resistance than thicker plasma spray coatings.