CLINICIAN MANAGED INTERPERSONAL PSYCHOTHERAPY

描述(改编自申请者摘要)：实证研究 评估急性心理治疗的效果提供了 证明这种治疗方法对主要疾病的疗效的宝贵数据 抑郁症。在受控条件下，限时人工为主 心理疗法在缓解抑郁症方面是有效的 症状。然而，这样的功效研究有几个局限性。第一, 虽然这些治疗在实验室环境下是有效的，但其有效性 在这些治疗方法中，疗效研究由于缺乏外部因素而受到限制。 有效性。第二，尽管限时治疗的急性影响 抑郁是令人印象深刻的，改善通常不会保持，而且 症状复发是很常见的。 我们建议的研究项目是对 临床医生管理的人际心理治疗(CM-IPT)对精神分裂症患者的疗效 产后抑郁症，一种基于Klerman等人手册的治疗方法(1)和 针对社区环境进行了改进。会议的时间和频率将是 由治疗师和患者共同决定，而不是任意决定 由手动指令指定。我们将评估12项措施的有效性 与“标准”相比，在一年内提供的CM-IPT会议 产后抑郁症的IPT治疗，这是我们以前使用的一种治疗方法 与等待名单控制条件相比，证明是有效的。 标准IPT将要求在前12个IPT中提供2个IPT会话 治疗任务后几周。 本研究申请的第一个主要目的是评估 CM-IPT治疗产后抑郁症的纵向疗效比较 标准IPT。我们预测，CM-IPT将与较低的累积 抑郁症状的程度和第一年较低的抑郁率 而不是标准IPT。这项研究申请的第二个主要目的是 证明CM-IPT对产后抑郁症的急性疗效。我们 将在治疗分配后12周比较CM-IPT和标准IPT (标准IPT治疗的结论)，届时我们预计两人 治疗要在临床上等同。我们的研究，它独特地结合了 最佳元素的有效性和有效性研究，将导致更多 对社区产后抑郁妇女的有效治疗。

DESCRIPTION (Adapted from the Applicant's Abstract): Empirical studies evaluating the effects of acute psychotherapeutic treatment have provided invaluable data demonstrating the efficacy of such treatments for major depression. Under controlled conditions, time-limited manual-based psychotherapies are efficacious in bringing about remission of depressive symptoms. Such efficacy studies, however, have several limitations. First, though the treatments are efficacious in laboratory settings, the effectiveness of such treatments, efficacy studies are limited by their lack of external validity. Second, though the acute effects of time-limited treatments for depression are impressive, the improvement is often not maintained, and recurrence of symptoms is common. Our proposed research project is an empirical investigation of the effectiveness of Clinician-Managed Interpersonal Psychotherapy (CM-IPT) for postpartum depression, a treatment based on the manual of Klerman et al (1) and refined for a community setting. Timing and frequency of sessions will be determined collaboratively by the therapist and patient rather than arbitrarily specified by manualized directives. We will evaluate the effectiveness of 12 sessions of CM-IPT delivered over the course of a year compared to "standard" IPT for postpartum depression, a treatment which we have previously demonstrated to be efficacious compared to a waiting list control condition. Standard IPT will require that 2 sessions of IPT be delivered in the first 12 weeks after treatment assignment. The first major aim of this research application is to evaluate the longitudinal effectiveness of CM-IPT for postpartum depression compared to standard IPT. We predict that CM-IPT will be associated with lower cumulative levels of depressive symptoms and lower rates of depression over the first year than standard IPT. The second major aim of this research application is to demonstrate the acute effectiveness of CM-IPT for postpartum depression. We will compare CM-IPT and standard IPT at 12 weeks after treatment assignment (the conclusion of standard IPT treatment), at which time we expect the two treatments to be clinically equivalent. Our study, which uniquely combines the best elements of both efficacy and effectiveness research, will lead to more effective treatment for depressed postpartum women in the community.