BRAIN INJURY IN TORTURE SURVIVORS: MENTAL HEALTH IMPACT

超出所提供的空间。拟议的研究是第一个针对酷刑幸存者群体的社区研究，该研究调查了酷刑中常见的头部损伤对精神和功能结果的影响。该研究将确定越南酷刑幸存者的酷刑和头部伤害事件的数量。它将检验以下假设：a)头部受伤的酷刑幸存者比没有头部受伤的酷刑幸存者或对照者有更高程度的精神症状和功能障碍；B)头部受伤的酷刑幸存者在神经心理测试和神经影像学上的脑部异常与没有头部受伤的幸存者和对照组不同；c)患有抑郁症和创伤后应激障碍的酷刑幸存者在神经心理测试和神经影像学上的大脑异常与没有这些诊断的幸存者和对照组不同。该设计是一项横断面研究，对马萨诸塞州主要越南移民安置机构名单上的所有越南酷刑幸存者（即前政治犯）进行全面普查（n= 400），并对年龄/性别相似的非前政治犯、未遭受酷刑和未头部受伤的越南移民进行对照组（n=125）。所有受试者将接受初步调查，测量个人和环境风险因素，酷刑和头部损伤的自我报告，以及精神和功能结果。接下来，所有受试者将接受文化公平的神经心理学测试，该测试能够发现包括执行功能、复杂注意力和记忆在内的缺陷。根据一般调查的结果，将样本分为六个比较组：有/没有精神症状的头部损伤酷刑、有/没有精神症状的头部损伤酷刑、有/没有精神症状的对照组。从六组中随机选择受试者（n=140）进行神经影像学检查（脑MRI和DSC fMRI）。将使用图形方法、描述性统计、方差分析、逻辑回归和结构方程模型来检验假设。网站性能 ======================================== 节结束 ===========================================

EXCEED THE SPACE PROVIDED. The proposed research is the first community study of a population of torture survivors that investigates the impact of head injury, common in torture, on psychiatric and functional outcomes. The study will determine the amount of torture and head injury events in Vietnamese torture survivors. It will test the hypotheses that a) torture survivors with head injury have higher levels of psychiatric symptoms and functional impairment than torture survivors or controls without head injury; b) torture survivors with head injury will have brain abnormalities on neuropsychological testing and neuroimaging distinct from survivors and controls without head injury; and c) torture survivors with depression and PTSD will have brain abnormalities on neuropsychological testing and neuroimaging distinct from survivors and controls without these diagnoses. The design is a cross-sectional study of a complete census of all Vietnamese torture survivors (i.e., ex-political detainees) on the roster of Massachusetts' leading Vietnamese resettlement agency (n = 400) and a control group of similar age/gender Vietnamese immigrants who are not ex-political detainees, have not been tortured and have not had head injury (n=125). All subjects will receive an initial survey which measures personal and environmental risk factors, self-report of torture and head injury, and psychiatric and functional outcomes. Next, all subjects will receive culture-fair neuropsychological tests capable of detecting deficits including executive function, complex attention and memory. Based on the results of the general survey, the sample will be divided into six comparison groups: torture with head injury with/without psychiatric symptoms, torture without head injury with/without psychiatric symptoms, controls with/without psychiatric symptoms. Subjects from each of the six groups (n=140) will be randomly selected to undergo neuroimaging (brain MRI and DSC fMRI). Graphical methods, descriptive statistics, ANOVA, logistic regression, and structural equation models will be used to test the hypotheses. PERFORMANCE SITE ========================================Section End===========================================