Oregon Human Investigations Program

描述(由申请人提供)： 在过去的10年里，临床研究和翻译研究的复杂性对临床研究人员掌握一套新的研究技能提出了额外的要求。K30资助的人类调查计划(HIP)是四年前建立的，旨在满足OHSU教职员工和研究员以及社区附属机构的需求。该计划由教学部分和指导研究经验组成；我们建议在下一个资助期增加经验部分。教学课程围绕公认的研究核心能力而开发：临床研究研究设计、生物统计学、医学信息学、人类研究伦理以及科学写作和交流。此外，我们还增加了翻译研究和卫生服务研究。HIP项目的选修课包括数据管理、随机临床试验、循证医学和有效的临床教学。所有的住院医师和研究员研究课程都被整合到这个项目中。HIP课程是由资深、经验丰富的教育工作者利用成人教育的原则创建和教授的。在指导的研究经验中，每个学生都与导师一起工作，要么写一份NIH式的拨款，要么设计、实施和撰写一份关于临床研究项目的手稿。在拟议的体验式学习中，HIP学员将有机会参与拨款审查、IRB会议或分子生物学实验室工作。所有受训者都会评估课程中的课程，整个项目在每年年底的焦点小组环境中进行评估。HIP项目的完成导致授予人类调查培训证书；临床研究硕士学位已在OHSU获得批准，并正在等待俄勒冈大学系统的批准。 目前，HIP已有86人进入学位队列，48人进入非学位队列。在最初录取学位的31人中，78%已经毕业或仍然活跃在该计划中；在第二个队列29人中，90%仍然活跃；在第三个队列中，26人中，96%仍在注册。在完成该计划的第一批人中，80%的人至少提交了一项研究资助，73%的人目前获得了研究支持。

DESCRIPTION (provided by applicant): The complexities of clinical research and translational research over the past 10 years have placed additional demands for mastery of a new set of research skills for clinical investigators. The K30-funded Human Investigations Program (HIP) was established four years ago to meet the needs of OHSU faculty and fellows, and community affiliates. The program consists of a didactic component coupled with a mentored research experience; we propose to add an experiential component in the next grant period. The didactic courses were developed around the accepted core competencies for research: clinical research study design, biostatistics, medical informatics, ethics of human research, and scientific writing and communication. To these, we add translational research and health services research. Elective courses in the HIP program include data management, randomized clinical trials, evidence-based medicine and effective clinical teaching. All residency and fellowship research courses have been consolidated into this program. The HIP courses are created and taught by senior, experienced educators using principles of adult education. In the mentored research experience, each student is works with a mentor to write either an NIH-style grant or to design, implement, and write a manuscript on a clinical research project. In the proposed experiential learning, HIP trainees will have opportunities to participate in grant review, IRB meetings, or molecular biology lab work, as examples. All trainees evaluate the courses in the curriculum and the entire program is evaluated in a focus group setting at the end of each year. Completion of the HIP program results in awarding a Certificate of Training in Human Investigation; a Master of Clinical Research has been approved at OHSU and is pending approval by the Oregon University System. At present, HIP has enrolled 86 into the degree cohort and 48 into the non-degree cohort. Of the initial cohort of 31 who matriculated in the degree track, 78% have graduated or remain active in the program; of the second cohort of 29, 90% remain active; of the third cohort, of 26, 96% remain enrolled. In the first cohort to complete the program, 80 % have submitted at least one research grant, and 73% currently have research support.