Health Effects of Occupational Exposures in PGDP Workers

描述：Paducah气体扩散厂(PGDP)位于肯塔基州西部，距离Paducah市以西约10英里。它目前雇佣了大约1700名工人；自1952年工厂成立以来，大约有8000人在那里工作。该工厂位于农村地区，毗邻受保护的保护区、野生动物和娱乐区。PGDP的主要功能是生产浓缩铀，供商业反应堆使用，或作为进一步浓缩铀的其他工厂的原料。工人、政府官员和周围社区都对核电站目前和过去的暴露可能对健康造成的影响表示担忧。这里提出的研究将完成一项持续的死亡率调查，以帮助解决这些担忧，方法是将工作历史与历史暴露数据相结合，为工厂的每个工人创建贯穿设施历史的暴露指标。在具体目标1中，我们将对照其他现有名单和原始文件验证工人名册。在具体目标2中，我们将从纸质记录和电子文件中为工作人员制定一份全面的工作和工作历史清单。在具体目标3中，我们将为工厂整个历史中的化学和辐射暴露创建一个工作暴露矩阵。在具体目标4中，我们将把工作历史数据与工作暴露矩阵联系起来，以估计单个工人的暴露指标。在具体目标5中，我们将使用标准化死亡率和风险评估方法评估工人死亡率与工作场所暴露的关系。在具体目标6中，我们将把研究结果传达给员工和管理层。 这些调查的首要目标是评估历史暴露对工人死亡率的影响。PGDP是美国仅存的没有经过全面职业健康研究的气体扩散工厂。PGDP调查产生的数据将与朴茨茅斯和橡树岭气体扩散工厂设施之前的两项研究合并。Paducah数据将大大增强综合数据库的统计能力，以解决铀浓缩工人迫切的健康问题。

DESCRIPTION: The Paducah Gaseous Diffusion Plant (PGDP) is located in Western Kentucky, about 10 miles west of the City of Paducah. It currently employs approximately 1700 workers; some 8,000 individuals have worked at the plant since it was opened in 1952. The plant is located in a rural area, adjacent to protected conservation, wildlife and recreation areas. The primary function of the PGDP has been to produce enriched uranium for use by commercial reactors or as feed material for other plants that further enrich the uranium. Workers, government officials and the surrounding community have raised concerns about potential health effects from current and past exposures at the plant. The studies proposed here will complete an ongoing mortality investigation to help address those concerns, by combining work histories with historical exposure data to create an exposure metric for each worker at the plant, throughout the history of the facility. In Specific Aim 1, we will validate the worker roster against other existing name lists and source documents. In Specific Aim 2, we will develop a comprehensive list of jobs and job histories for the workforce from paper records and electronic files. In Specific Aim 3, we will create a Job Exposure Matrix for chemical and radiation exposures throughout the history of the plant. In Specific Aim 4, we will link the Work History data with the Job Exposure Matrix to estimate individual worker exposure metrics. In Specific Aim 5, we will evaluate worker mortality for relationships with workplace exposures using standardized mortality ratios and risk assessment approaches. In Specific Aim 6, we will communicate the study results to employees and management. The overarching goal of these investigations is to evaluate the impact of historical exposures on worker mortality. The PGDP is the only remaining gaseous diffusion plant in the US that has not undergone a comprehensive occupational health study. The data generated by the PGDP investigations will be available to merge with the two prior studies at the Portsmouth and Oak Ridge gaseous diffusion plant facilities. The Paducah data will add substantially to the statistical power of the combined database to address the pressing health concerns of uranium enrichment workers.