Ped Endocrine Career Development in Diabetes Research

描述（由申请人提供）： 该职业发展计划的目标是培养新一代的儿科内分泌学家，他们将能够在新的世纪开展与儿童糖尿病相关的创新，科学严谨的以患者为导向和以实验室为基础的研究。该计划的需求之一是糖尿病研究中学术儿科内分泌学家的严重短缺，这已经被美国糖尿病协会，青少年糖尿病研究基金会和儿科学术协会等组织所强调。此外，该方案认识到，人类基因组计划等最新科学进展以及胰岛移植和生物力学和生物工程胰岛生产的成功，为推进儿童糖尿病研究提供了重要的新机会。该计划将支持学者在初级教师水平长达3年的研究职业发展。该项目的教师包括来自儿童医院和宾夕法尼亚大学医学院的19名科学导师，他们拥有出色的资历和积极的研究项目和培训记录。这些导师将通过与儿童糖尿病相关的基础实验室研究和/或以患者为导向的研究来监督学者的职业发展。职业发展机会将包括基础研究的3个主要领域：1）信号转导：激素作用机制; 2）胰腺β细胞功能和发育的调节; 3）糖尿病和内分泌疾病的遗传方法。面向患者的研究机会将包括以下领域：1）胰岛免疫学，移植和调节; 2）肥胖和胰岛素抵抗; 3）糖尿病并发症;和4）糖尿病流行病学和生物统计学。该计划包括在研究的各个方面的正式培训课程，包括生物统计学，生物伦理学，分子生物学等该计划得到了机构资源的广泛支持，包括CHOP GCRC和UPenn DERC。要求每年在该计划中获得2个被任命者名额。

DESCRIPTION (provided by applicant): The goal of this Career Development Program Is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative, scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children for this new 21st Century. One of the needs for this Program is the critical shortage of academic pediatric endocrinologists in diabetes research which has been emphasized by the organizations such as the American Diabetes Association, the Juvenile Diabetes Research Foundation, and the Pediatric Academic Societies. In addition, the Program recognizes the important new opportunities for advancing diabetes research in children provided by such recent scientific advances as the Human Genome Project and the successes in islet transplantation and production of biomechanical and bioengineered islets. The Program will support Scholars for up to 3 years of research career development at the junior faculty level. The Program faculty includes 19 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials and active research programs and training records. These mentors will supervise Scholars' career development through basic laboratory research and/or patient-oriented research related to diabetes in children. Career development opportunities will include 3 major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action; 2) Regulation of Pancreatic beta-Cell Function and Development; and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation; 2) Obesity and Insulin Resistance, 3) Diabetes Complications; and 4) Diabetes Epidemiology and Biostatistics. The Program includes a curriculum of formal training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 2 Appointee slots in this Program each year.