Treatment for Adolescent Anorexia Nervosa

描述(由申请人提供)：神经性厌食症(AN)是一种严重的心理疾病，估计在15-19岁的青春期女性中患病率为0.48%。在青少年中，这种疾病严重影响身体、情感和社会发展。到目前为止，还没有针对患有AN的青少年的大规模治疗研究。然而，较小规模的研究表明，一种特定类型的基于家庭的治疗(FT)是治疗青少年发病AN的有效方法。这项多点研究旨在比较这种特定的家庭疗法(FBT)和以自我为导向的个人心理疗法(EOIT)，以确定哪种疗法更有效。 本研究有两个具体目的：(1)比较FBT和EOIT在青少年AN中的相对疗效。我们将具体检查体重增加、对体重和体型的心理担忧以及家庭功能的变化。(2)考察结果的潜在预测者、调解者和调节者。 为了实现这些目标，建议进行以下研究：在两个中心(每个中心60个)，120名12-18岁符合DSM-IV AN标准的青少年被随机分配到两个治疗组之一：1)FBT(手动)，为期12个月的24个计划患者时间；或2)EOIT(手动)，为期12个月，24个计划患者时间。 治疗结束后对所有患者进行为期1年的随访。评估将在基线、治疗结束以及六个月和一年的随访中进行。主要结果将是体重变化。次要结果将是体重和体型的变化，这是通过饮食失调检查衡量的。

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychological condition with a prevalence estimated at 0.48% among adolescent females between 15-19 years. In adolescents, the illness severely affects physical, emotional, and social development. To date, there are no large-scale treatment studies of adolescents with AN. Smaller scale studies, however, suggest that a specific type of family-based treatment (FT) is an effective approach to adolescent onset AN. This multi-site study aims to compare this specific family therapy (FBT) with ego oriented individual psychotherapy (EOIT) to determine which treatment is more efficacious. The study has two specific aims: (1) To compare the relative efficacy of FBT and EOIT in adolescents with AN. We will specifically examine weight gain, psychological concerns about weight and shape and changes in family functioning. (2) To examine potential predictors, mediators and moderators of outcome. To accomplish these aims the following study is proposed: at two centers (60 per center), 120 adolescents between the ages of 12-18 meeting DSM-IV criteria for AN will be randomly assigned to one of two treatment groups: 1) FBT (manualized) for 24 planned patient hours for 12 months; or 2) EOIT (manualized) for 24 planned patient hours over 12 months. All patients will be followed for 1 year after the end of treatment. Assessment will occur at baseline, end of treatment, and six months and one-year follow-up. Primary outcome will be weight change. Secondary outcomes will be changes in weight and shape concerns as measured by the Eating Disorder Examination.