Template Synthesis of Recognition-Encoded Oligomers

该项目将从分子生物学中提取概念，并将其应用于一类新分子的有机化学。核酸的独特性质使其成为复杂纳米纤维的首选材料。通过互补序列之间的非共价相互作用高保真形成双链体提供了多组分自组装和模板合成的分子编程的直接方法。核酸骨架和碱基的结构可以在不破坏这些性质的情况下改变，这表明存在各种未探索的有机分子，它们也将显示序列选择性双链体形成。这个项目将探索新的寡聚分子的合成与识别位点的定义序列配备。目的是建立使用一种寡聚体模板合成相同序列或互补序列的拷贝的方案。这种模板化学将提供使用模板聚合常规单体的工具，以确定识别位点的序列，并因此将核酸的选择性识别特性并入具有复制和进化潜力的新系统中。

The project will take concepts from molecular biology and apply them to the organic chemistry of a new class of molecules. The unique properties of nucleic acids have made them the material of choice for complex nanofabrication. High fidelity formation of duplexes via non-covalent interactions between complementary sequences provides a straightforward approach to molecular programming of multicomponent self-assembly and template synthesis. The structure of the nucleic acid backbone and bases can be changed without destroying these properties, suggesting that there are all kinds of unexplored organic molecules that will also show sequence selective duplex formation. This project will explore the synthesis of new oligomeric molecules equipped with defined sequences of recognition sites. The aim is to establish protocols for using one oligomer to template the synthesis of a copy of the same sequence or complementary sequence. This template chemistry will provide tools for polymerisation of conventional monomers using templates to determine the sequence of recognition sites and hence incorporate the selective recognition properties of nucleic acids into new systems that have the potential for replication and evolution.