A randomised, double-blind study to optimise prescribing of morphine for breathlessness

尽管对导致呼吸困难的根本原因进行了最佳治疗，但仍有超过300000澳大利亚人在休息或轻微劳累时长期呼吸困难，其中70000人无法离开家。世界上还没有注册的药物来治疗这种疾病。有证据表明，常规、低剂量的吗啡可以安全地帮助呼吸困难。这项研究将帮助临床医生更有效地调整剂量，并了解使用额外的药物来减少焦虑是否有助于缓解呼吸困难。

More than 300000 Australians are chronically short of breath at rest or on minimal exertion despite optimal treatment of the underlying causes of their breathlessness, of whom 70000 cannot leave home. No medication in the world is registered to treat this. There is evidence that regular, low dose morphine safely helps breathlessness. This study will help clinicians adjust doses more effectively and understand whether using an additional medication to reduce anxiety helps relieve breathlessness.