Strength Training for Obesity Prevention

描述(由调查人员提供)：最近肥胖率上升 已经使预防肥胖成为一个明确而紧迫的公共卫生问题。这个 美国女性平均每年增重约0.5公斤，其中60%到80%可以 被认为是胖的。25岁至44岁的超重女性患糖尿病的几率更高。 体重显著增加(BMI增加超过5公斤/平方米) 年纪较大或较瘦的女性。腹部总脂肪增加和内脏脂肪增加相关 有各种各样的肥胖共病，包括胰岛素抵抗， 高血压和血脂异常。成功减肥的难度 几位专家建议继续减肥 专家小组建议超重和轻度肥胖者避免并存 避免体重增加，而不是减肥。观察体力活动 随着年龄的增长而下降，而卡路里摄入量保持稳定或略有下降。 有强有力的观察证据表明，体力活动可以防止或 减少与年龄相关的脂肪增加。这种随机的、受控的行为 干预试验将检验这样一种假设，即定期参与 每周两次力量训练计划超过2年，可以防止年龄相关 超重的80人体内脂肪(总和内脏腹部脂肪)增加到 25岁至25岁之间的中度肥胖绝经前妇女(BMI 25-35公斤/平方米) 与标准护理组(n=80)相比，年龄为44岁。该计划的总体目标是 研究是为了防止身体脂肪增加和减少与以下相关的健康风险 肥胖。治疗效果将评估胰岛素敏感性、血液 血压、血脂、肌肉力量和心理社会预测因素 坚持力量训练。这种方法的创新之处在于其 简单性和充分参与的最短时间要求(2个练习 每周会议)。对这一创新方法的初步研究导致了 88%的锻炼课程参与者超过12个月，并保持 治疗对体脂百分比的影响至前期研究结束 测量(9个月)。这支持了Long的可行性和潜力 建议的干预方法的长期有效性。其长期影响 这项疗效试验的成功之处在于，这种适度的行为改变 可以防止肥胖增加和相关的并发症，通常在 中年女性。

DESCRIPTION (provided by investigator): Recent obesity prevalence increases have made obesity prevention a clear and pressing public health issue. The average US woman gains about 0.5 kg per year, 60 to 80 percent of which can be assumed to be fat. Overweight women aged 25 to 44 have a higher prevalence of significant weight gains (BMI increases of greater than 5 kg/m2) than men or older or thinner women. Total and visceral abdominal fat gains are associated with a variety of obesity co-morbidities, including insulin resistance, hypertension, and dyslipidemia. The difficulty in successfully losing weight and maintaining weight loss has resulted in recommendations from several expert panels to advise overweight and mildly obese individuals free of co-morbidities to avoid weight gains rather than to lose weight. Physical activity is observed to decline with age while caloric intake remains stable or declines slightly. There is strong observational evidence that physical activity could prevent or attenuate age associated fat gains. This randomized, controlled behavioral intervention trial will test the hypothesis that regular participation in a twice weekly strength training program over 2 years, can prevent age associated body fat increases (total and visceral abdominal fat) in 80 overweight to mildly obese premenopausal women (BMI 25-3 5 kg/M2) between the ages of 25 and 44 years compared to a 'standard care' group (n=80). The overall aim of the study is to prevent body fat gains and to reduce health risks associated with obesity. Treatment effects will be assessed for insulin sensitivity, blood pressure, blood lipids, muscle strength, and psychosocial predictors of strength training adherence. The innovation of this approach rests in its simplicity and the minimal time requirement for full participation (2 exercise sessions weekly). A preliminary study of this innovative approach resulted in 88 percent exercise session attendance over 12 months and maintenance of treatment effects on total body fat percentage to the end of pilot study measurements (9 Months). This supports the feasibility and potential for long term efficacy of the proposed intervention approach. The long-term implication of success in this efficacy trial would be that this modest behavior change could prevent the fat gains and associated co-morbidities commonly observed in midlife women.