Ruthenium-catalysed C-H functionalization of aromatic molecules with anilinium-electrophiles

目的：本项目将研究苯胺衍生的亲电试剂作为钌催化的C-H功能化反应的偶联配体，以及它们在药物和其他生物活性分子的合成或后期功能化中的应用。方法：将制备各种苯胺衍生的亲电试剂，并使用一系列钌催化剂进行测试。本项目将优化反应条件，包括温度、溶剂、共添加剂等。将进一步研究成功的亲电试剂类别，以确定它们的范围和潜力，以及它们在工业相关化合物中的应用。Remit：本项目福尔斯催化和合成有机化学领域。

Objective:This project will investigate the use of anilinium-derived electrophiles as coupling partners for Ru-catalyzed C-H functionalization reactions, and their application to the synthesis or late-stage functionalization of drugs and other biologically active molecules.Approach:A wide variety of anilinium-derived electrophiles will be prepared and tested with a range of Ru-catalysts. Reaction conditions will be optimized, including temperature, solvent, co-additives.Successful classes of electrophiles will be further investigated to map their scope and potential as well as their applications to industrially relevant compounds.Remit:This project falls within the areas of Catalysis and Synthetic Organic Chemistry.