CORE--Principal Research

主要研究试图增加循证干预的数量和可用性 适用于患有抑郁症及其并发症的高危人士，以及情绪难以治疗的人士 在专科精神卫生部门看到的障碍，以及在初级保健部门看到的#年 康复中心，以及养老院和其他长期护理机构。 干预研究将涉及以下主题：(1)预防老年人抑郁和自杀 高危；改善、预防或延缓老年抑郁症患者的认知和功能损害； (2)改善对晚年难以治疗的情绪障碍的治疗(例如，双相情感障碍，精神性抑郁， 和对一线治疗仅部分有效的单相重度抑郁)；以及(3)识别和移除 社区临床环境中有效治疗抑郁症的障碍。贯穿这些主题的是中心 目标(4)利用基础设施支持增加心理健康和老龄化方面的研究-培训机会 以及基于社区的参与性研究。 这些主题抓住了我们从功效到有效性研究，再到服务、传播和 NIMH理事会报告Bridqin.q Science and Service中规定的实践研究。为此， 主要研究核心和研究网络发展核心之间的双向联系包括 至关重要的科学重要性。

Principal Research seeks to increase the number and availability of evidence-based interventions applicable to elderly persons at high risk for depression and its complications, to those with difficult to treat mood disorders seen within the specialty mental health sector, and to those seen in the primary care sector, in rehabilitation centers, and in nursing home and other long term care settings. Intervention studies will address the following themes: (1) preventing depression and suicide in elderly persons at high risk; and improving, preventing, or delaying cognitive and functional impairments in elderly with depression; (2) improving treatment for difficult to treat mood disorders in later life (e.g., bipolar disorders, psychotic depression, and unipolar major depression responding only partially to first line treatment); and (3) identifying and removing barriers to effective depression treatment in community clinical settings. Cutting across these themes is the Center objective (4) of using infrastructure support to enhance research-training opportunities in mental health and aging and in community-based participatory research. These themes capture our movement from efficacy to effectiveness research, to services, dissemination, and practice research, as mandated in the NIMH Council report, Bridqin.q Science and Service. To this end the bidirectional linkages between the Principal Research Core and the Research Network Development Core are of critical scientific importance.