Core Facilities for Neurobiology at Brandeis

描述（由申请人提供）：我们要求资金建立三个核心设施，以支持10个NINDS资助的研究项目（研究人员：Rosbash，Birren，Griffith，Hall，Lisman，Marder，Sengupta，Turrigiano，Welte，白色）在布兰迪斯大学。 三个新的设施提出：一个微阵列/流式细胞仪设施，转基因小鼠设施，和一个综合的，多仪器成像设施。 要求为每个设施的设备、人员和用品提供资金。 每个设施将有一个监督委员会，每个监督委员会的主席，Sengupta，Birren和Turrigiano以及Rosbash将组成指导委员会，监督整个设施的管理。 这组NINDS资助的研究人员在突触传递神经调制机制、早期神经发育和突触形成、行为遗传学以及神经元功能的分子底物方面有着共同的兴趣。 拟议中的新设施不重复布兰迪斯大学校园内的任何现有设施，并且对于我们采用现在成为我们领域标准的最先进的新方法进行我们资助的研究至关重要。 这些设施也将加强其他NIH资助的研究人员在布兰迪斯大学的研究。 布兰代斯大学通过提供资金用于翻新空间和设备，对这些新设施做出了实质性的承诺。

DESCRIPTION (provided by applicant): We request funds to establish three core facilities to support 10 NINDS-funded research projects (investigators: Rosbash, Birren, Griffith, Hall, Lisman, Marder, Sengupta, Turrigiano, Welte, White) at Brandeis University. Three new facilities are proposed: A microarray/FACS facility, a transgenic mouse facility, and an integrated, multi-instrument imaging facility. Funds are requested for equipment, personnel, and supplies for each of the facilities. Each facility will have an oversight committee, and the chair of each of these oversight committees, Sengupta, Birren, and Turrigiano together with Rosbash, will constitute the Steering Committee to oversee the administration of the entire facility. This group of NINDS- funded investigators share common interests in the mechanisms of synaptic transmission neural modulation, early neural development and synapse formation, genetics of behavior, and the molecular substrates of neuronal function. The proposed new facilities do not duplicate any existing facilities on the Brandeis University campus and are essential to allow us to conduct our funded research employing the new state of the art methods now becoming standard in our field. These facilities will also enhance research by other NIH funded investigators at Brandeis University. Brandeis University has made a substantial commitment to these new facilities by providing funds for renovation of space and equipment.