Core--Statistics, Epidemiology, and Data Management

描述（由申请人提供）：这是统计流行病学的修订申请。和数据管理（SED）核心。SED核心将通过提供最先进的统计、流行病学和数据管理方面的建议和帮助，推进艾滋病毒研究并提高艾滋病毒中心附属研究人员提交的申请的质量。该中心将继续作为规划和设计研究者发起的观察性研究和行为干预的卓越中心，以降低个人、夫妻、群体和社区层面的艾滋病毒感染风险。它将确定以前未认识到的统计需求，并在最早的规划阶段研究设计改进，以便产生创新的解决办法。SED核心将以集中和统一的方式满足中心附属研究的生物统计学、流行病学和数据管理需求，符合现代行为干预研究随机对照试验的实施原则和比较或描述性、非实验性的观察方法

DESCRIPTION (provided by applicant): This is a revised application for the Statistics Epidemiology. and Data Management (SED) Core. The SED Core will advance HIV research and improve the quality of applications submitted by HIV Center-affiliated researchers by providing advice and assistance with state-of-the-art statistics, epidemiology, and data management. The Core will continue to serve as a center of excellence for the planning and design of investigator-initiated observational studies and behavioral interventions to reduce the risk of HIV infection on the individual, couple, group, and community levels. It will identify previously unrecognized statistical needs and study design improvements at the earliest planning stages in order to generate innovative solutions. The SED Core will meet the biostatistical, epidemiologic, and data management needs of Center-affiliated studies in a centralized and unified manner, consistent with modern principles of conduct of randomized controlled trials for behavioral intervention studies and observational methods for comparative or descriptive, nonexperimental studies. With its tripartite structure, the Core provides an interrelated network of talented specialists who are interdisciplinary and collaborate on all aspects of marshaling evidence: study design and instrumentation, anticipation and avoidance of bias, data management, statistical analysis and weighing of evidence, and interrelation with other disciplines to evaluate evidence and make causal inferences. The Statistics Component increases the likelihood that the randomized trials and observational studies will achieve their scientific goals through the application of good statistical principles and practices that minimize threats to validity. The biostatistical faculty and staff in the Core are highly experienced in collaborating with investigators in keeping studies on target and are pro-active in identifying and seeking resolutions to new statistical problems. The Epidemiology Component sits at the interface of the behavioral and biomedical sciences and thus is uniquely positioned to contribute to the articulation and refinement of research questions, to the selection of appropriate study designs, to the resolution of issues that arise in the field, and to the interpretation of the resulting data. The Data Management Component provides state-of-the-art management of research information, including forms production, ACASI instrumentation, and web-based research products. The integration of these skills and resources into one Core has led to a synergistic interaction of disciplines to identify and develop specific technical methods and products that will enhance the research productivity of the Center and support new and innovative research.