Statistics, Epidemiology, and Data Management Core

统计、流行病学和数据管理核心

• 批准号: 8550987
• 负责人: BRUCE LEVIN
• 金额: $ 2.66万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8550987
• 关键词: AIDS/HIV problem; Behavior; Behavior Therapy; Behavioral; Behavioral Sciences; Chairperson; Clinical; Clinical Trials Data Monitoring Committees; Communities; Data; Data Analyses; Data Base Management; Data Quality; Developing Countries; Development; Discipline; Doctor of Medicine; Doctor of Philosophy; Epidemiology; Faculty; Fostering; Future; Goals; Grant; HIV; HIV Infections; Individual; Infectious Disease Epidemiology; Intervention Studies; Joints; Leadership; Marshal; Methods; Mission; Observational Study; Online Systems; Performance; Positioning Attribute; Preparation; Prevention; Production; Productivity; Public Health Schools; Randomized Controlled Trials; Recommendation; Research; Research Design; Research Infrastructure; Research Personnel; Resolution; Resources; Risk; Role; Science; Solutions; Specialist; Staging; Structure; Technology; comparative; data management; design; epidemiologic data; experience; high standard; improved; innovation; instrumentation; meetings; member; multi-site trial; randomized trial; relational database; response; skills; statistics; transmission process

The Statistics, Epidemiology, and Data Management Core (SED) will advance HIV research and improve the quality of proposals submitted by HIV Center-affiliated researchers by providing advice and assistance with state-of-the-art statistics, epidemiology, and data management. The Core will continue to serve as a center of excellence for the planning and design of investigator-initiated observational studies and behavioral interventions to reduce the risk of HIV infection on the individual, couple, group, and community levels. It will identify previously unrecognized statistical needs and study design improvements at the earliest planning stages in order to generate innovative solutions. The SED Core will meet the biostatistical, epidemiologic, and data management needs of Center-affiliated studies in a centralized and unified manner, consistent with modern principles of conduct of randomized controlled trials for behavioral intervention studies and observational methods for comparative or descriptive, nonexperimental studies. With its tripartite structure, the Core provides an interrelated network of talented specialists who are interdisciplinary and collaborate on all aspects of marshaling evidence: study design and instrumentation, anticipation and avoidance of bias, data management, statistical analysis and weighing of evidence, and interrelation with other disciplines to evaluate evidence and make causal inferences. The Statistics Component increases the likelihood that the randomized trials and observational studies will achieve their scientific goals through the application of good statistical principles and practices that minimize threats to validity. The biostatistical faculty and staff in the Core are highly experienced in collaborating with investigators in keeping studies on target and are pro-active in identifying and seeking resolutions to new statistical problems. The Epidemiology Component sits at the interface of the behavioral and biomedical sciences and thus is uniquely positioned to contribute to the articulation and refinement of research questions, to the selection of appropriate study designs, to the resolution of issues that arise in the field, and to the interpretation of the resulting data. The Data Management Component provides state-of-the-art management of research information, including forms production, relational database management and web-based research products. The integration of these skills and resources into one Core has led to a synergistic interaction of disciplines to identify and develop specific technical methods and products that will enhance the research productivity of the Center and support new and innovative research. The SED Core also organizes preparation for Performance, Safety & Monitoring Board meetings and coordinates responses to PSMB queries and recommendations.

统计、流行病学和数据管理核心（SED）将推进艾滋病毒研究， 艾滋病中心附属研究人员通过提供咨询和 提供最先进的统计、流行病学和数据管理方面的援助。核心将继续 作为一个卓越的中心，规划和设计的发电机启动的观测 研究和行为干预措施，以减少个人、夫妇、群体感染艾滋病毒的风险， 和社区层面。它将确定以前未被认识到的统计需求和研究设计 在最早的规划阶段进行改进，以产生创新的解决方案。SED核心 将满足中心附属研究的生物统计学、流行病学和数据管理需求， 集中统一的方式，符合现代随机对照的行为原则 行为干预研究的试验和比较性或描述性、非实验性 问题研究通过其三方结构，核心提供了一个相互关联的人才网络， 跨学科的专家，在整理证据的各个方面进行合作：研究设计 和仪器，预测和避免偏倚，数据管理，统计分析和 权衡证据，并与其他学科的相互关系，以评估证据，使因果关系 推论统计组件增加了随机试验和 观察性研究将通过应用良好的统计学原理来实现其科学目标 和最大限度地减少对有效性威胁的做法。生物统计的教师和工作人员在核心是高度 在与研究者合作保持研究目标方面经验丰富，并积极主动地 发现并寻求解决新的统计问题的办法。流行病学部分位于 行为和生物医学科学的接口，因此具有独特的地位，有助于 研究问题的表达和细化，选择适当的研究设计， 解决现场出现的问题，并解释产生的数据。数据 管理组件提供最先进的研究信息管理，包括表单 生产、关系数据库管理和基于网络的研究产品。整合这些 技能和资源整合为一个核心，导致学科之间的协同互动，以确定和发展 具体的技术方法和产品，将提高研究中心的生产力， 支持新的创新研究。SED核心还组织性能、安全 &监测委员会会议，并协调对PSMB查询和建议的回应。