Statistics, Epidemiology, and Data Management Core

统计、流行病学和数据管理核心(SED)将推动艾滋病毒研究和改进 艾滋病毒中心附属研究人员提交的建议的质量通过提供建议和 在最先进的统计、流行病学和数据管理方面提供帮助。核心将继续 作为研究人员发起的观测计划和设计的卓越中心 研究和行为干预，以降低个人、夫妇、群体、 和社区层面。它将确定以前未确认的统计需求和研究设计 在最早的规划阶段进行改进，以产生创新的解决方案。SED核心 将满足中心附属研究的生物统计、流行病学和数据管理需求 集中统一的方式，符合现代随机控制的行为原则 比较或描述性非实验行为干预研究和观察方法的试验 学习。凭借其三方结构，核心提供了一个相互关联的人才网络 跨学科的专家，在整理证据的各个方面进行合作：研究设计 和工具、预测和避免偏差、数据管理、统计分析和 权衡证据，以及与其他学科的相互关系，以评估证据和确定因果关系 推论。统计部分增加了随机试验和 观察性研究将通过应用良好的统计学原理来实现其科学目标 以及将对有效性的威胁降至最低的做法。核心的生物统计学教职员工高度重视 有与调查人员合作保持目标研究的经验，并积极参与 识别和寻求解决新的统计问题的方法。流行病学部门位于 行为科学和生物医学科学的接口，因此处于独特的地位，有助于 研究问题的表达和提炼，到选择适当的研究设计，到 解决实地出现的问题，并解释所产生的数据。数据 管理组件提供最先进的研究信息管理，包括表单 生产、关系数据库管理和基于网络的研究产品。这些功能的整合 技能和资源合二为一的核心导致了学科之间的协同互动，以确定和开发 具体的技术方法和产品将提高中心的研究生产力和 支持创新研究。SED核心还组织性能、安全方面的准备工作 监督委员会会议并协调对PSMB询问和建议的答复。

The Statistics, Epidemiology, and Data Management Core (SED) will advance HIV research and improve the quality of proposals submitted by HIV Center-affiliated researchers by providing advice and assistance with state-of-the-art statistics, epidemiology, and data management. The Core will continue to serve as a center of excellence for the planning and design of investigator-initiated observational studies and behavioral interventions to reduce the risk of HIV infection on the individual, couple, group, and community levels. It will identify previously unrecognized statistical needs and study design improvements at the earliest planning stages in order to generate innovative solutions. The SED Core will meet the biostatistical, epidemiologic, and data management needs of Center-affiliated studies in a centralized and unified manner, consistent with modern principles of conduct of randomized controlled trials for behavioral intervention studies and observational methods for comparative or descriptive, nonexperimental studies. With its tripartite structure, the Core provides an interrelated network of talented specialists who are interdisciplinary and collaborate on all aspects of marshaling evidence: study design and instrumentation, anticipation and avoidance of bias, data management, statistical analysis and weighing of evidence, and interrelation with other disciplines to evaluate evidence and make causal inferences. The Statistics Component increases the likelihood that the randomized trials and observational studies will achieve their scientific goals through the application of good statistical principles and practices that minimize threats to validity. The biostatistical faculty and staff in the Core are highly experienced in collaborating with investigators in keeping studies on target and are pro-active in identifying and seeking resolutions to new statistical problems. The Epidemiology Component sits at the interface of the behavioral and biomedical sciences and thus is uniquely positioned to contribute to the articulation and refinement of research questions, to the selection of appropriate study designs, to the resolution of issues that arise in the field, and to the interpretation of the resulting data. The Data Management Component provides state-of-the-art management of research information, including forms production, relational database management and web-based research products. The integration of these skills and resources into one Core has led to a synergistic interaction of disciplines to identify and develop specific technical methods and products that will enhance the research productivity of the Center and support new and innovative research. The SED Core also organizes preparation for Performance, Safety & Monitoring Board meetings and coordinates responses to PSMB queries and recommendations.