Heart Rate Variability Response to CAM in Pediatrics

中期职业研究者奖（K24）将为Kathi Kemper博士继续她在儿科补充和替代医学方面的开创性研究提供稳定的支持。她是《整体儿科医生》、八个普通和专业儿科教科书章节以及70多个同行评议的科学出版物的作者。她还是NIH NLM资助项目的首席研究员，NIH-NCCAM资助R25的研究中心首席研究员，并获得非NIH竞争性资金。她指导过许多研究生、研究员和初级教员。她发起并成为波士顿整体儿科教育和研究中心的第一任主任。她是门诊儿科协会（阿帕）的前任主席，阿帕研究常务委员会的前任主席，以及美国儿科学会的现任成员。肯珀博士发起并共同主持了维克森林大学医学院（WFUSM）生物能量研究理事会，并在2003-2004年为医学生讲授了一门关于治疗和治疗触摸的选修课。在2003年期间，她进行了一项关于儿童肿瘤患者心率变异性（HRV）稳定性的初步研究;这项研究为未来研究这些患者对音乐和治疗触摸疗法的反应中HRV的变化提供了必要的数据。K24的三个项目包括：1）描述急性白血病儿童的HRV与人口统计学、疾病和心理社会因素之间关系的横断面研究; 2）在同一人群中评估音乐对HRV和心理状态的影响的前瞻性队列研究（急性和在随后的两次访问中使用额外的“剂量”）; 3）一项平行的前瞻性队列研究，评估Healing Touch对同一人群中这些结果的影响。所有这些研究将为计划和进行这些疗法的随机对照试验提供关键数据。我们预计，肯珀博士和她的学员将根据本申请中提出的工作申请额外的NIH奖。肯珀的计划，反映在丰富的CAM研究阵列正在进行和计划在几个部门和中心，众多的支持信，并已提交研究资金的申请。K24奖将使她从临床，教学和行政需求中解脱出来，并使她能够将时间和注意力集中在本申请中描述的研究和指导活动上。

DESCRIPTION (provided by applicant): The Mid-Career Investigator award (K24) will provide stable support for Dr. Kathi Kemper to continue her seminal research in complementary and alternative medicine for pediatrics. She is the author of The Holistic Pediatrician, eight general and specialty pediatric textbook chapters, and over 70 peer-reviewed scientific publications. She is also the principal investigator on an NIH NLM- funded project, a site principal investigator on an NIH-NCCAM funded R25, and has non-NIH competitive funding. She has mentored many graduate students, fellows and junior faculty members. She initiated and was the first Director for the Center for Holistic Pediatric Education and Research in Boston. She is the past President of the Ambulatory Pediatric Association (APA), past Chair of the APA standing committee on Research, and a current member of the American Pediatric Society. Dr. Kemper initiated and co-chairs the Council on Bioenergetic Research at Wake Forest University School of Medicine (WFUSM), and in 2003-2004 taught an elective course for medical students on Therapeutic and Healing Touch. During 2003, she conducted a pilot study on the stability of heart rate variability (HRV) in pediatric oncology patients; this study provides essential data for future studies on changes in HRV in response to music and Healing Touch therapies for these patients. The three projects for the K24 include: 1) a cross-sectional study describing the relationship between HRV and demographic, disease and psychosocial factors in children with acute leukemia; 2) a prospective cohort study evaluating the effect of music on HRV and psychological state in the same population (both acutely and with additional "doses" at two subsequent visits); 3) a parallel prospective cohort study evaluating the effect of Healing Touch on these outcomes in the same population. All of these studies will provide data critical to planning and conducting randomized controlled trials of these therapies. We anticipate that Dr. Kemper and her mentees will apply for additional NIH awards based on the work proposed in this application. The WFUSM and the Department of Pediatrics are highly supportive of Dr. Kemper's plans, as reflected in the rich array of CAM research underway and planned in several departments and Centers, the numerous letters of support, and applications for research funding already submitted. The K24 award will free her from clinical, teaching and administrative demands, and allow her to focus her time and attention on research and mentoring activities described in this application.