Dynamic Measures of Neurochemistry in Mood Disorders

描述：（由申请人提供）我的研究工作是针对 解开情绪和时间，节奏变化之间的关系， 脑脊液单胺水平目前的项目合并血清素和抑郁症 从以前的工作在耶鲁大学的利益与技术，在脑脊液采样发展 在范德比尔特。试验数据表明，单胺的振荡模式 代谢物水平可能比绝对浓度更重要。我们 能够在范德比尔特使用q10在48小时内监测CSF神经化学 分钟样品，以证明单胺代谢物的动态振荡 水平使用傅里叶变换方法，并隔离主导周期长度 这些周期。这些方法是非常有前途的硬 科学/工程方法来理解动态相互作用之间 导致抑郁的单胺系统。 K23研究职业奖将为我的研究创造专门的时间 成为该领域的独立研究员。虽然我有很好的 精神病学技能，我的培训计划将需要额外的知识， 应用数学和统计学，使我能够进一步分析 神经化学数据，并开发更好的方法来评估振荡， 单胺能功能授标期间的计划包括以下教学课程： 这些领域以及负责任和道德的研究行为。的 研究战略将在导师的指导下制定，导师专门从事 不同的领域，但谁，一起可以帮助我产生高质量的研究， 新颖的方法。我的长期职业目标是荣誉我的遗产 导师带来了新一代的研究人员的挑战， 奖励的发现，并进一步了解的生理基础 目的是发现更可靠和直接的方法 来缓解抑郁症

DESCRIPTION: (provided by applicant) My research effort is directed toward unraveling the relationships between mood and temporal, rhythmic changes in monoamine levels in CSF. The current project merges serotonin and depression interests from previous work at Yale with techniques in CSF sampling developed at Vanderbilt. Pilot data indicate that oscillatory patterns in monoamine metabolite levels may be more important than absolute concentrations. We are able at Vanderbilt to monitor CSF neurochemistry over 48-hour periods with q10 minute samples, to demonstrate dynamic oscillations in monoamine metabolite levels using Fourier transform methods, and to isolate dominant period lengths of these cycles. These methods are extremely promising as a hard science/engineering approach to understanding the dynamic interactions between monoamine systems that contribute to depression. The K23 Research Career Award will create dedicated time needed for my research career to become an independent researcher in this area. Although I have good psychiatric skills, my training program will require additional knowledge in applied mathematics and statistics to enable me to analyze further the neurochemical data and develop better methods for assessing oscillations in monoaminergic function. Plans for the award period include didactic courses in these areas as well as in the responsible and ethical conduct of research. The research strategy will develop under the guidance of mentors who specialize in different areas but who, together can help me produce quality research with a novel approach. My long range career goals are to honor the legacy of my mentors by bringing a new generation of researchers to the challenge and rewards of discovery, and to further the understanding of the physiologic basis of mood regulation with the aim of discovering more reliable and direct means for alleviating depression.