Heart-Lung Physiology: Molecular-Systemic Integration

描述（由申请人提供）： 这是自1999年7月以来一直在运作的心肺生理学培训研究生和博士后研究员（MD和Ph.D）的竞争更新申请。 该建议继续侧重于将细胞和分子信息整合到身体整体功能中的培训。 基本原理：从系统到细胞和分子生理学的研究重点的转变导致了系统生理学中训练有素的个人的稳步下降，而此时用于监测生理功能的遗传技术和非侵入性方法已经发展，从而产生了对在这一领域受过训练的个人的主要需求。 该计划的主要目标仍然是：“1）提供跨学科科学的培训，重点是心肺功能的整合 在分子，细胞，器官和整个动物或人类水平的系统，和2）提供了一个广泛的基础上的结构和功能的心肺系统，重点是“解决问题的技能”。 拟议的教师已经建立了心肺生理学的研究计划，并培养了一些成功的科学家。 他们采用了大量的方法来研究心肺系统，从全身生理学到细胞和分子生物学再到计算建模。 他们代表CWRU医学院的6个基础科学和2个临床科学部门。 该培训计划促进了拟议教师之间现有的合作，并继续对CWRU心肺生理学的培训和未来研究产生重大影响。 预doetoral学员将参加研究生课程，并将提供专门设计的课程，用于心肺生理学，分子和细胞生物学基础，实验室轮换，研讨会，期刊俱乐部和大轮和监督研究的综合方面。 该项目的博士后培训生分为两类：1）心脏病学和/或肺科临床研究员; 2）博士学位。博士后研究生。 博士后研究培训辅以适当的高级课程，研讨会，期刊俱乐部和大轮。 本次培训共招收博士生8名，博士后7名（博士4名，医学博士3名），其中一半已顺利完成培训。 我们提出的培训计划，强调跨部门的障碍和科学学科，继续发展全面的科学家在心肺生理学的综合方面的培训。

DESCRIPTION (provided by applicant): This is a competing renewal application for training graduate students and post-doctoral fellows (MD and Ph.D) in cardio-respiratory physiology that has been in operation since July 1999. This proposal continues to focus on training in integration of cellular and molecular information to the overall function of the body. Rationale: A shift in research emphasis from systems to cellular and molecular physiology has resulted in a steady decline of well trained individuals in systems physiology at a time when genetic technology and non-invasive approaches for monitoring physiological functions have advanced creating a major need for individuals trained in this area. The major goals of this program continues to be: "1) providing training in interdisciplinary sciences with a focus on integrating function of the cardiorespiratory systems at the molecular, cellular, organ, and whole animal or human levels, and 2) provide a broad-based foundation in structure and function of cardio-respiratory systems with an emphasis on "problem-solving skills". The proposed faculty have established research programs in cardio-respiratory physiology and trained a number successful scientists. They employ a vast repertoire of approaches to study cardio-respiratory systems ranging from whole body physiology to cellular and molecular biology to computational modeling. They represent 6 basic science and 2 clinical Science departments at CWRU School of Medicine. This training program facilitate already existing collaborations amongst the proposed faculty and continues to have a major impact on training and future research in cardio-respiratory physiology at CWRU. The pre-doetoral trainees will be enrolled in the graduate program and will be offered courses specifically designed for integrated aspects of cardio-respiratory physiology, fundamentals of molecular and cell biology, laboratory rotations, seminars, journal clubs and grand rounds and supervised research. Post-doctoral trainees in this program are of two kinds: 1) cardiology and/or pulmonary clinical fellows; and 2) Ph.D. post-doctoral trainees. Research training for post-doctoral trainees is supplemented with appropriate advanced courses, seminars, journal clubs, and grand rounds. In the current training period, 8 pre-doctoral trainees and 7 post-doctoral trainees (4 Ph.D's and 3 MDs) have been recruited, and half of them have successfully completed training. Our proposed training program, which emphasizes crossing of departmental barriers and scientific disciplines, continues to develop well-rounded scientists trained in integrated aspects of cardio-respiratory physiology.