Training Program in Developmental Biology

描述（由申请人提供）：这是一个有竞争力的更新，在发育生物学的博士前和博士后培训计划。拟议的培训计划包括来自大学内多个学校和部门的教师，反映了宾夕法尼亚大学发育生物学研究和培训的重大扩展。这种扩张包括细胞和发育生物学系的形成和发育生物学的研究生培训计划。拟议的博士前和博士后培训经验主要集中在使用脊椎动物，无脊椎动物和植物有机体的胚胎发育的基本机制的实验室研究的培训。它促进了现代遗传，细胞和分子方法在发育研究中的应用。研究培训领域包括控制细胞谱系确定、分化和迁移、器官发生、细胞衰老、形态发生和模式形成的转录和细胞信号传导机制。受训人员还有机会接触基因疗法、胎儿外科手术和发育中的遗传疾病方面的相关临床研究。在准备他们的研究培训，博士前学生接受正规的教学研究的既定课程，包括在发育生物学和遗传，细胞和分子方法发展机制和疾病的高级研讨会讲座课程。博士前和博士后学生还参加发育生物学杂志俱乐部，研讨会计划，选定主题的研究讨论小组和年度科学研讨会。学员每学期在学员和培训员的非正式会议上介绍他们的研究成果。这种培训的目的是使受训者为在学术和政府机构或生物技术行业中担任发育生物学领域的独立调查员做好准备。

DESCRIPTION (provided by applicant): This is a competitive renewal for a pre- and postdoctoral training program in developmental biology. The proposed training program includes faculty from multiple schools and departments within the University and reflects a major expansion of developmental biology research and training at Penn. This expansion includes the formation of a Department of Cell and Developmental Biology and a graduate training program in developmental biology. The proposed pre- and postdoctoral training experience is centered primarily on training in laboratory research in basic mechanisms of embryonic development using a diversity of vertebrate, invertebrate, and plant organisms. It fosters the application of modern genetic, cellular, and molecular approaches to developmental studies. Research training areas include transcription and cell signaling mechanisms that control cell lineage determination, differentiation and migration, organogenesis, cellular senescence, morphogenesis, and pattern formation. Trainees also have opportunities for exposure to relevant clinical research in gene therapy, fetal surgery and genetic diseases of development. In preparation for their research training, predoctoral students receive formal instruction in an established curriculum of study, including lecture courses in developmental biology and advanced seminars on genetic, cellular, and molecular approaches to developmental mechanisms and disease. Pre- and postdoctoral students also participate in a developmental biology journal clubs, a seminar program, research discussion groups on selected topics, and an annual scientific symposium. Trainees present their research findings each semester at an informal meeting of trainees and trainers. The objectives of this training are to prepare trainees for careers as independent investigators in the field of developmental biology in academic and governmental institutions or in the biotechnology industry.