Aerobic Exercise Intervention for Knee Osteoarthritis

描述(由申请人提供)： 关节炎是最常见的功能受限和 在美国的依赖。骨关节炎患者限制关节 运动和限制活动，以减轻他们的症状。传统的， 骨性关节炎的保守医学治疗一直是为了改善 通过减轻关节疼痛和炎症并维持功能状态 或恢复关节功能。运动在临床辅助治疗中的应用 然而，膝骨性关节炎患者的治疗并不是 一致接受。 相比之下，运动已被证明对预防和 心血管和代谢紊乱的治疗。存在标准指南 用于有氧运动处方。这项研究的重点是确定 这些指南也适用于膝骨性关节炎患者。 膝骨性关节炎患者将随机分为对照组，A组 步行运动组和静止骑自行车运动组。这个 运动组的个人将被要求每年锻炼三次 使用新兴的公共健康建议有氧运动，为期一年 成年人和老龄人口的锻炼。患者的结果将被评估 使用客观的步态分析测量，膝关节X线片来量化关节 空间狭窄，磁共振成像，一般健康状态 问卷(SF-36)、疾病/地点特定问卷(WOMAC)和 视觉模拟疼痛评分。所有受试者将在0周和52周进行学习。 这项工作的中心假设是有氧运动可以 作为一种有效的非手术治疗方案成功实施 早期膝骨性关节炎患者。为了评估这一点 假设，提出以下具体目标：具体目标1：确定 有氧运动对膝骨性关节炎患者的影响假设 答：参加锻炼的患者的临床结果指标会更好 控制病人的程序。假设B：LOWER的定量测量 在有效的有氧运动中，肢体功能不会随着时间的推移而下降 程序。具体目标2：确定影响预后的预后因素 膝骨性关节炎患者。假设：一种有效的练习 成人退行性关节疾病的处方依赖于膝盖 间隔参与、CIA分期、BMI和规定的运动类型。

DESCRIPTION (provided by applicant): Arthritis is one of the most common causes of functional limitation and dependency in the United States. Individuals with osteoarthritis restrict joint motion and limit activity in order to decrease their symptoms. Traditional, conservative medical treatment of osteoarthritis has been directed at improving functional status through reducing joint pain and inflammation and maintaining or restoring joint function. Exercise as an adjunct therapy in the clinical management of patients with osteoarthritis of the knee, however, is not uniformly accepted. In contrast, exercise has been shown to be effective for prevention and treatment of cardiovascular and metabolic disorders. Standard guidelines exist for aerobic exercise prescriptions. The focus of this study is to determine if these guidelines can also be applied to individuals with knee osteoarthritis. Patients with knee osteoarthritis will be randomized into a control group, a walking exercise group, and a stationary cycling exercise group. The individuals in the exercise groups will be required to exercise three times per week for one year using emerging public health recommendations for aerobic exercise in the adult and aging population. Patient outcome will be assessed using objective gait analysis measurements, knee radiographs to quantify joint space narrowing, magnetic resonance imaging, a general health status questionnaire (SF-36), a disease/site specific questionnaire (WOMAC), and a visual-analog pain scale. All subjects will be studied at 0 and 52 weeks. The central hypothesis of this work is that aerobic exercise can be successfully implemented as an effective nonsurgical option for treatment of patients with early stages of knee osteoarthritis. In order to evaluate this hypothesis, the following specific aims are proposed: Specific Aim 1: Determine the effect of aerobic exercise on patients with knee osteoarthritis. Hypothesis A: Clinical Outcome measures will be better in patients enrolled in exercise programs that in control patients. Hypothesis B: Quantitative measures of lower extremity function will not decline over time in an effective aerobic exercise program. Specific Aim 2: Determine prognostic factors that effect outcome in patients with knee osteoarthritis. Hypothesis: A effective exercise prescription for adults with degenerative joint disease is dependent on knee compartment involvement, CIA stage, BMI, and type of exercise prescribed.