NEUROBIOLOGY AND NEUROPSYCHOLOGY OF AGING

描述(来自申请表)：本培训项目旨在为博士后学生和博士后研究员提供神经生物学和老年神经心理学方面的专门培训。这项建议的核心是融合两个长期存在的NIA计划项目的调查人员的专业知识。一个是在马萨诸塞州总医院(MGH)，在拟议的培训补助金主任之一玛丽莲·阿尔伯特博士的指导下，专注于人类在健康和疾病中的衰老(AG-04953)，另一个是以波士顿大学医学院(波士顿大学医学院)为中心的非人类灵长类动物模型(AG-00001)的认知衰退的神经基础，另一位主任是莫斯博士。培训将侧重于研究领域，包括人类和动物模型正常衰老的神经心理学和神经生物学，与年龄相关的痴呆和神经疾病；神经遗传学和神经流行病学；细胞和突触超微结构与年龄相关变化的研究以及其他相关主题。波士顿大学医学院有6名培训员，哈佛医学院有3名培训员，BUSM附属退伍军人管理医院有4名培训员。该项目包括深入的课堂教学、动手实验室研究、互动网站、年度实地考察和务虚会，以及13名教员正在调查的一个或多个神经生物学和神经心理学领域的经验。此外，学生和研究员将参加北大和麻省理工学院举办的一系列关于老龄化的研讨会，以拓宽他们对当代老龄化研究的了解。还将鼓励受训人员参与教学，为他们担任教职做好准备。团队周围的所有受训人员的课程指导中心教授了关于衰老的神经生物学和神经心理学的入门课程，神经科学的课程，以及哈佛医学院老年学部举办的关于老龄的夏季研讨会系列。这些课程和研讨会包括讲座、讨论、对研究论文的评论和实验室演示。

DESCRIPTION (From the application): This training program has been developed to provide predoctoral students and postdoctoral fellows with specific training in the Neurobiology and Neuropsychology of Aging. At the core of this proposal is the merging of the expertise of investigators from two long standing NIA program projects. One is focused on human aging in health and disease (AG-04953) centered at Massachusetts General Hospital (MGH) under the direction of Dr. Marilyn Albert, one of the directors of the proposed training grant, and the other on the neural basis of cognitive decline in a non-human primate model (AG-00001) centered at Boston University School of Medicine (BUSM) of which Dr. Moss, the other director, is Co-PI. The training will focus on areas of research that include the neuropsychology and neurobiology of normal aging in humans and animal models, age-related dementia and neurologic disease; neurogenetics and neuroepidemiology; and studies of age-related changes in cellular and synaptic ultrastructure and other related topics. There are six trainers based at Boston University School of Medicine, three based at Harvard Medical School and four based at BUSM affiliated Veterans Administration Hospitals. The program includes in-depth classroom instruction, hands-on laboratory research, interactive web-site, annual field trip and retreat, and experience in one or more of the areas of the neurobiology and neuropsychology of aging being investigated by the 13 faculty. Additionally, students and fellows will attend a series of seminars on aging at BUSM and at MGH to broaden their knowledge of contemporary aging research. Trainees will also be encouraged to participate in teaching to prepare them for academic faculty positions. Class instruction for all trainees centers around the team taught introductory course in the Neurobiology and Neuropsychology of Aging, a course in Neuroscience, and a summer seminar series on Aging conducted by the Division on Aging at Harvard Medical School. These courses and seminars consist of lectures, discussions, critiques of research paper and laboratory demonstrations.