Molecular Mechs.Regulating Cancer Cell Proliferation

描述（由申请人提供）：这个博士后培训计划，“调节癌细胞增殖的分子机制”，由来自威斯康星大学麦迪逊分校10个系的22名科学家组成，他们对癌细胞生物学有普遍兴趣，对维持肿瘤细胞增殖的分子有特殊兴趣。 请求为6个培训职位提供资金。 这个项目的目标是培养博士，D.V.M.-还有医学博士水平的科学家在有关癌症生物学这方面的问题和技术，使他们能够成为独立的研究人员与自己的研究计划。 完成培训计划后，这些科学家应该能够在学术，政府或企业生物医学研究部门竞争最好的职位。 在分析调控分子（包括生长因子、生长因子受体、原癌基因、转录因子和细胞外基质中的分子）方面接受过培训的研究人员可能会从事影响我们对癌症病因学理解的研究，并建立适用于特定肿瘤分子检测和诊断的系统。 培训计划的目的是为每个受训者提供一个主要的导师（培训师），在其实验室中，受训者将在与导师实验室研究有关的具体问题和技术方面得到指导。 受训者将参与研究工作，并应对研究进展作出具体贡献，这些进展将提交给同行评审的期刊发表。 此外，培训计划还为学员提供了更广泛的接触肿瘤细胞生物学实验方法的机会，并通过强制参与计划活动，使学员更广泛地接触这些方法的临床应用。 最后，由项目主任和项目中的四名高级培训师组成的评估委员会将每年对每个受训人员在研究和项目其他活动中的进展情况进行评估。 该评估将通过口头和书面评估为受训者提供建设性的批评意见。 评估委员会的成员将努力帮助导师为学员提供最好的准备，为癌症研究的独立职业做好准备。

DESCRIPTION (provided by applicant): This Postdoctoral Training Program, "Molecular Mechanisms Regulating Cancer Cell Proliferation," consists of 22 scientists from 10 departments at the University of Wisconsin-Madison who have a general interest in cancer cell biology and specific interests in the molecules that maintain the proliferation of neoplastic cells. Funds are requested for six training positions. The goal of this program is to train Ph.D.-, D.V.M.- and M.D.-level scientists in the questions and techniques relevant to this aspect of cancer biology so that they can become independent researchers with their own research programs. Upon completion of the training program, these scientists should be able to compete for the best positions in academic, government, or corporate biomedical research departments. Investigators trained in the analysis of regulatory molecules, including growth factors, growth factor receptors, proto-oncogenes, transcription factors, and molecules in the extracellular matrix, may pursue research that will affect our understanding of cancer etiology and establish systems useful in the molecular detection and diagnosis of specific tumors. The training program is designed to provide each trainee with a primary mentor (trainer) in whose laboratory the trainee will be instructed in the specific questions and techniques relevant to the research of the mentor's laboratory. The trainee will participate in the research effort and should make specific contributions to the research progress, which will be submitted to peer-reviewed journals for publication. In addition, the training program provides to the trainees a broader exposure to experimental approaches in tumor cell biology and to the clinical application of these approaches through mandatory participation in the program activities. Finally, the progress of each trainee in his or her research and in the other activities of the program will be evaluated annually by an Evaluation Committee made up of the Program Director and four senior trainers in the program. This evaluation will provide the trainee with constructive criticism through oral and written evaluations. The members of the Evaluation Committee will strive to help the mentors provide the trainees with the best possible preparation for independent careers in cancer research.