Gordon Research Conferences: Collagen 2005, 2007

描述(申请人提供)：这是2005年和2007年戈登胶原蛋白研究会议的部分资助申请。2005年大会将于7月24日至29日在新伦敦的科尔比-索耶学院举行。与过去5次会议一样，预计2007年会议将在7月最后一周的同一地点举行。2005年胶原戈登研究会议将是这次顶级会议的35周年纪念日。该会议每隔一年召开一次，它是一个独特的论坛，供对结缔组织病理生物学有共同兴趣的国际科学家小组进行互动。在胶原蛋白的基础生物学、发育和疾病方面，细胞外基质研究中的重大发现经常在这次会议上首次报道。2005/2007年会议将重点介绍以下方面的新信息：胶原蛋白在细胞外基质内和与细胞的相互作用；细胞外基质的功能和组装；胶原蛋白基因组的结构；胶原蛋白的比较基因组学；蛋白质的翻译后加工；编码这些蛋白质的基因在发育过程中的调节；作为再生医学生物材料和作为基因治疗靶点的胶原蛋白；以及胶原蛋白突变或基因缺失在人类和模式生物体中的表型和代谢后果。国际公认的结缔组织生物学家以及未来的研究人员将被邀请介绍目前该领域的前沿工作。会议为在现有科学家之间以及在现有科学家和新科学家之间开展富有成效的合作提供了宝贵的机会；这些合作反过来又进一步促进了该领域的科学进步。

DESCRIPTION (provided by applicant): This is an application for partial support of the Gordon Research Conferences on Collagen in 2005 and 2007. The 2005 Conference will be held at Colby-Sawyer College in New London, NH, July 24th to 29th. The 2007 conference is expected to be at the same location during the last week in July, as has been the case for the last 5 conferences. The 2005 Collagen Gordon Research Conference will be the 35th anniversary of this premier conference. The conference has convened every other year and it is a unique forum for interaction of an international group of scientists with a common interest in the pathobiology of connective tissues. Major discoveries in extracellular matrix research are often reported for the first time at this conference in the basic biology, development, and diseases of collagen. The 2005/2007 conferences will emphasize new information regarding the interactions of collagens within extracellular matrices and with cells; the function and assembly of the extracellularmatrix; structure of the collagen genome; comparative genomics of collagen; posttranslational processing of proteins; the regulation of genes encoding these proteins during development; collagen as biomaterial in regenerative medicine and as a target for gene therapy; and the phenotypic and metabolic consequences of collagen mutations or gene deletion in humans and model organisms. Internationally recognized connective tissue biologists as well as up-and-coming investigators will be invited to present current work at the forefront of the field. The Conference has provided an invaluable opportunity for development of productive collaborations among established scientists and between established and new scientists; those collaborations have in turn, further enhanced the scientific progress in the field.