Clearance of Dying Cells by Phagocytes-Gordon Conference

描述（由申请人提供）：本提案要求支持两年一次的戈登吞噬细胞清除死亡细胞研究会议，从该主题的第二次会议开始，于2005年6月19日至24日在康涅狄格州新伦敦的康涅狄格学院举行。会议将吸引基础和临床科学家研究凋亡细胞被识别和吞噬的机制，以及清除功能失调导致的疾病状态。会议的目标包括介绍该领域核心主题的最新进展，如识别分子、信号通路和吞噬机制；探索一个或多个卫星兴趣，如自噬；将研究核心分子问题的人员与研究凋亡细胞吞噬在免疫耐受、炎症、肿瘤免疫学和自身免疫等生理和临床领域中的作用的人员聚集在一起；并提供交流的机会，部分是通过邀请演讲者，特别是对刚进入该领域或地理位置偏僻的研究人员。要涵盖的主题包括(1)PS受体；(2)凋亡靶点的鉴定；(3)无脊椎动物的识别；(4)吞噬机制；(5)吞噬机制的历史与扩散；(6)自身免疫;(7)凋亡细胞识别与疾病；(8)自噬。

DESCRIPTION (provided by applicant): This proposal requests support over 5 years for the biennial Gordon Research Conference on Clearance of Dying Cells by Phagocytes, beginning with the second Conference of this subject, to be held June 19-24, 2005, at Connecticut College in New London, CT. The conference will attract both basic and clinical scientists investigating mechanisms by which apoptotic cells are recognized and engulfed as well as the disease states that are a consequence of dysfunctional clearance. The goals of the conference include the presentation of current progress on the core topics of the field, such as recognition molecules, signaling pathways and engulfment machinery; exploration of one or more satellite interests, such as autophagy; bringing together those who study the core molecular questions with those who study the role of apoptotic cell engulfment in physiological and clinical areas such as immune tolerance, inflammation, tumor immunology, and autoimmunity; and providing a networking opportunity, in part by speaker invitations, particularly for investigators who are new to the field or geographically isolated. Topics to be covered include (1) the PS Receptor; (2) Identification of the Apoptotic Target; (3) Recognition in Invertebrates; (4) Phagocyte Engulfment Mechanisms; (5) History and Proliferation of Engulfment Mechanisms; (6) Autoimmunity; (7) Apoptotic Cell Recognition and Disease; and (8) Autophagy.