Skeletal Development and Remodeling in Health, Disease and Aging

描述(申请人提供)：纽约科学院(NYAS)计划于2005年5月18日至3月21日在纽约市举行一次题为“健康、疾病和老龄化中的骨骼发育和重塑”的会议。这次会议由Mone Zaidi，医学博士，FRCP，医学教授和西奈山医学院西奈山骨骼项目主任组织。 现在是就这一主题举行会议的理想时机，因为过去十年，我们对骨架是如何改造和修复的了解有了极大的扩展。利用包括转基因、基因敲除和基因阵列在内的最先进的分子技术，科学家们正在更好地了解成骨细胞铺设新骨和破骨细胞如何移除旧骨的确切途径。这些研究有助于阐明骨骼的基本生物学特性，以及它对激素、细胞因子和机械刺激的反应，以及明确的路径生理学。这些发现的最终目标是为识别未来药物开发的新细胞和分子靶点奠定坚实的科学基础。 会议将围绕四个主题组织：骨骼发育和修复、骨分子内分泌学、骨细胞生物学和骨骼完整性保护，同时使与会者能够在每个类别内进行高度集中的讨论。最后一天将特别关注目前和正在出现的骨质疏松症治疗方法。这次会议将吸引骨和软骨生物学研究领域的高能量贡献者以及在该领域工作的初级教员和高级博士后研究员的广泛参与。我们还预计生物学家、化学家和医生也将参加会议，他们的研究和/或患者将从会议交换的信息中受益。还计划举办一个地方论坛，为非科学公众提供一个非正式的机会，了解该领域正在出现的最新研究和疗法。

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a conference titled, "Skeletal Development and Remodeling in Health, Disease and Aging" to be held from May 18 to March 21, 2005 in New York City. The conference is being organized by Mone Zaidi, MD, PhD, FRCP, Professor of Medicine and Director, Mount Sinai Bone Program, Mount Sinai School of Medicine. It is an ideal time for a conference on this subject, as the past decade has seen an enormous expansion in our understanding of how the skeleton is remodeled and repaired. Using state-of-the-art molecular technologies including Tran genesis, gene knockout, and gene array, scientists are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have helped clarify basic biological properties of the skeleton, how it responds to hormonal, cytokine and mechanical stimulation, as well as clarified path physiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. The conference will be organized along four themes: Skeletal Development and Repair, Molecular Endocrinology of Bone, Bone Cell Biology and Conservation of Skeletal Integrity, while enabling participants to engage in a highly focused discussion within each category. The final day will specifically focus on current and emerging therapies for osteoporosis. The conference will draw wide spread participation among high powered contributors in bone and cartilage biology research, as well as junior faculty member and senior postdoctoral research fellows working in the field. We also expect the meeting to be attended also by biologists, chemists, and medical doctors whose research and/or patients stand to benefit from the information exchanged at the conference. A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned.