Stress Proteins: Growth, Development & Disease GRC 2005

描述（由申请人提供）：所有生物体都暴露于应激条件下，包括环境应激，如高温和辐射，生理应激，如代谢反应引起的氧化应激，或病理生理应激，如药理学作用，感染和炎症。这些应激条件导致蛋白质错误折叠、聚集、细胞功能障碍和细胞死亡。最近的研究强烈表明，通过激活信号转导途径、转录因子和在蛋白质稳态中起作用的基因产物来感知和响应应激信号的能力，对于正常生长、发育和预防包括癌症、心血管疾病和蛋白质折叠疾病（如阿尔茨海默氏症、亨廷顿舞蹈症和朊病毒疾病）在内的疾病至关重要。模型系统的研究已经建立了寿命和建立强大的应激反应能力之间的强相关性。戈登研究会议“生长、发育和疾病中的应激蛋白”将于2005年7月17日至22日举行。组织者是Dennis J. Thiele（杜克大学医学中心）和Peter Walter（加州大学旧金山分校）。会议将着重讨论压力感应、信号和基因表达、蛋白质构象疾病、压力基因在代谢、生长和发育中的作用、压力基因对感染的调节、压力的细胞生物学以及压力在衰老中的作用等方面的最新进展。计划举行8次会议，并为新的研究人员、学员和最近的突破保留额外的演讲机会。到目前为止，邀请的20多位演讲者都是各自领域的领导者，其中30%是女性。演讲者、博士后和研究生之间将有大量的机会进行详细的、非正式的讨论，在海报会议和会议期间的额外时间，以加强互动和信息传递。本申请要求为戈登研究会议提供部分支持。

DESCRIPTION (provided by applicant): All organisms are exposed to stressful conditions including environmental stresses such as elevated temperatures and irradiation, physiological stress such as oxidative stress due to metabolic reactions, or pathophysiological stresses such as pharmacological agents, infection and inflammation. These stressful conditions lead to protein misfolding, aggregation, cellular dysfunction and cell death. Recent studies strongly suggest that the ability to sense and respond to stress signals, through the activation of signal transduction pathways, transcription factors and gene products that function in protein homeostasis is critical for normal growth, development and in the protection against diseases that include cancer, cardiovascular disease and protein folding diseases such as Alzheimer's, Huntington's and prion based disease. Studies in model systems have established a strong correlation between longevity and the ability to mount robust stress responses. This Gordon Research Conference on "Stress Proteins in Growth, Development and Disease" will be held July 17-22, 2005. The organizers are Dennis J. Thiele (Duke University Medical Center) and Peter Walter (University of California-San Francisco). The meeting will emphasize vigorous discussions of recent developments in stress sensing, signaling and gene expression, diseases of protein conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection, the cell biology of stress and the roles of stress in aging. Eight sessions are planned with additional speaking opportunities reserved for new investigators, trainees and recent breakthroughs. Of more than twenty speakers invited to date, all leaders in their respective field, 30% are women. There will be abundant opportunities for detailed, informal discussions among speakers, postdoctoral fellows and graduate students at poster sessions and additional times during the meeting to enhance interactions and information transmission. This application requests partial support for this Gordon Research Conference.