COLUMBIA UNIVERSITY ASTHMA AND ALLERGY CLINICAL RESEARCH

总体描述（由申请人提供）：特应性哮喘和其他过敏性 疾病是由个体对环境的病理反应引起的。 抗原要治愈这些疾病，需要了解 启动这些免疫反应所需的机制， 传播它们所需的机制。最近的一个主要范例是 在这一领域的研究已经产生的是，无论是启动和 过敏性免疫应答的传播需要不同免疫应答的相互作用。 炎症细胞此外，这种互动需要交换 这些细胞之间的信息。信息交流的核心 过敏性免疫反应中细胞之间的联系是使用信号传导 将这些信号传递到细胞核的途径。这 意识到这一点，开始推动治疗研究朝着以下方向发展： 改变这些信号通路，以改变所产生的过敏反应， 免疫反应该研究中心旨在了解 过敏和哮喘免疫反应中的信号通路。在项目1中， 博士Schindler建议研究STAT信号在发展中的作用， 树突状细胞（DC）的功能。在项目2中，Pernis博士将研究 在正常和过敏人群中调节CD 23。在项目3中， 将研究Fc受体在启动和传播中的作用， 过敏和哮喘免疫反应。在项目4中，罗斯曼博士将研究 Pim激酶如何改变IL-4信号传导以及这如何改变过敏性免疫 应答在项目5中，米勒博士将研究 未出生的孩子该中心获得的知识将提高我们的 了解过敏性免疫所需的信号通路 反应一个科学核心和一个行政核心将支持这些活动。 项目科学核心将提供技术专门知识和援助 在哮喘和过敏性免疫反应的小鼠模型中。行政 核心将协助组织中心？的活动。

OVERALL DESCRIPTION (provided by applicant): Atopic asthma and other allergic diseases are caused by a pathologic response of individuals to environmental antigens. To cure these diseases will require an understanding of the mechanisms that are required to initiate these immune responses and the mechanisms required to propagate them. One of the major paradigms that recent research in this field has generated is that both the initiation and propagation of allergic immune responses requires the interaction of different inflammatory cells. In addition, this interaction requires the exchange of information between these cells. Central to the exchange of information between cells involved in an allergic immune response is the use of signaling pathways to transmit these signals to the nucleus of the cells. This realization has begun to drive therapeutic research in the direction of altering these signaling pathways in order to modify the resultant allergic immune response. This Research Center seeks to understand the role of signaling pathways in allergic and asthmatic immune responses. In Project 1, Dr. Schindler proposes to study the role of STAT signaling in the development and function of Dendritic Cells (DC). In Project 2, Dr. Pernis will study the regulation of CD23 in normal and allergic humans. In Project 3, Dr. Clynes will study the role of Fc receptors in the initiation and propagation of allergic and asthmatic immune responses. In Project 4, Dr. Rothman will study how Pim kinases alter IL-4 signaling and how this alters allergic immune responses. In Project 5, Dr. Miller will study the immune response of the unborn child. The knowledge gained by this Center will improve our understanding of the signaling pathways required for an allergic immune response. A Scientific Core and an Administrative Core will support these projects. The Scientific Core will provide technical expertise and assistance in murine models of asthma and allergic immune responses. The Administrative Core will assist in organizing the Center?s activities.