ADAMTS-5 activity and the effect of a dominant-negative mutant

关节炎的一个特征是关节炎的关节炎。我们发现，一个关键的软骨成分的损失是由酶ADAMTS-5引起的。我们还发现ADAMTS-5的突变形式可能通过一种新的结合相互作用阻断正常的酶。如果我们能够理解这种相互作用是如何起作用的，我们就可以利用它来设计新的关节炎疗法。该项目旨在确定新型相互作用并提高对软骨破坏的了解。

Cartilage loss is a feature of arthritis and is caused by enzymes. We discovered that loss of a critical cartilage component is caused by the enzyme ADAMTS-5. We also discovered that a mutant form of ADAMTS-5 blocks the normal emzyme, possibly by a novel binding interaction. If we can understand how this interaction works, we can exploit it for the design of new arthritis therapies. This project aims to identify the novel interaction and improve out understanding of cartilage destruction.