Translational Breast Cancer Research Training Program

描述(由申请者提供)：女性结果的改善 乳腺癌将需要一种新兴的新一代的研究人员， 翻译研究员。在这两个方面都有扎实基础的科学家 对临床有一定了解的分子和细胞研究人员 疾病将指引乳腺癌研究最有效的未来。是这样的 调查人员被称为“翻译型”，因为他们有能力 将基本发现转化为临床策略。这类培训 需要资金雄厚的核心研究人员进行基础实验室 研究，以及出色的临床培训计划。在贝勒学院 医学方面，最近成立的乳房中心就提供了这样的组合。 在这项申请中，到第三年，我们建议支持12名博士或医学博士。 博士后实习生。所有受训人员将致力于乳腺癌的一个方面。 从激素作用和治疗应用中选择，生长因子， 信号转导，细胞周期控制，正常乳房发育，乳房 癌症预防、乳腺癌进化、分子遗传学或基因 心理治疗。涵盖科学写作和研究的正规教学课程 补助金、生物统计学、乳腺癌临床问题和组织病理学 将需要对乳腺癌的进化进行研究。工作的进展和方向 学员的研究项目将每两周密切监测一次 评论。受训人员还将参加每周一次的乳腺癌临床病例培训。 会议，以增加他们对临床问题的了解。 因为我们的综合性，以及医学和医学的平衡包容 博士导师，学员将有大量的机会与之互动 他们的临床同行讨论翻译问题。因此，通过 在以下指导下提供涉及实验室培训的计划 有长期乳腺癌病史的知名导师 研究，与成功的内科科学家的互动，以及接触 临床乳腺癌问题，我们将创造一个独特的机会 培养新的翻译研究人员。

DESCRIPTION (provided by applicant): Improvements in the outcome for women with breast cancer will require an emerging new breed of investigator, the translational researcher. Scientists with a strong foundation in both basic molecular and cellular research who also have an understanding of the clinical disease will direct the most effective future of breast cancer research. Such investigators have been called "translational" because of their ability to translate basic findings into clinical strategies. This type of training requires both a well-funded core of investigators performing basic laboratory research, and an excellent clinical training program. At Baylor College of Medicine, the recently established Breast Center affords such a combination. In this application, by the third year, we propose to support 12 Ph.D. or M.D. postdoctoral trainees. All trainees will work on an aspect of breast cancer chosen from hormone action and therapeutic applications, growth factors, signal transduction, cell cycle control, normal breast development, breast cancer prevention, breast cancer evolution, molecular genetics, or gene therapy. Formal didactic courses covering scientific writing and research grants, biostatistics, problems in clinical breast cancer, and histopathology of breast cancer evolution will be required. Progress and direction of the trainee's research project will be closely monitored in bi-weekly data reviews. Trainees will also attend a weekly clinical breast cancer case conference in order to increase their understanding of clinical issues. Because of our integrative nature, and the balanced inclusion of M.D. and Ph.D. mentors, the trainees will have abundant opportunities to interact with their clinical counterparts for discussion of translational issues. Thus, by providing a program that involves laboratory training under the direction of well-established mentors with a long-standing track record of breast cancer research, interaction with successful physician-scientists, and exposure to clinical breast cancer issues, we will have created a unique opportunity to train new translational researchers.