Biochemical and Behavioral Mechanisms of Toxicology

描述(由申请人提供) 这项拟议培训计划的目的是促进 以生化和行为研究为重点的毒理学 阿肯色大学医学科学(UAMS)毒理学通过 机构国家研究服务奖。这将会实现的 通过发展或扩展博士前的研究技能和知识 并因此为他们从事富有成效的研究事业做好准备。 跨学科毒理学研究生项目(INTOX)是一个联合项目 在UAMS和国家毒物学中心的副教授之间 学生在任一大学进行论文研究的研究 机构。此外，调查人员还制定了药理学培训计划 (制药)。将积极招聘博士前学生并对其进行评估 根据他们的GPA，GRE成绩录取研究生院， 推荐信，以及以前的研究经验。博士后 学生在第一年将得到UAMS奖学金的支持。在 完成第一年的学习后，学生将在毕业时接受评估 学校记录，最重要的是，他们在研究轮换中的表现 参加培训补助金。前两名学生将被录取 对培训补助金的支持，并将在第2年、第3年和第4年提供支持，条件是 他们希望在UAMS专攻生化和行为毒理学。 他们在接受培训补助金期间的进展将由他们的 参与研讨会、研究和课程工作表现，作者 手稿和摘要，以及年度报告。毒理学培训 专门研究生化毒理学的教员有：Hinson(Hepato-， 代谢-，信号转导)，Schnellmann(肾脏，分子，信号 转导)，Jeschke(肝、免疫、信号转导)，Samokyszyn (代谢、肿瘤学)、格兰特(分子、代谢)、欧文斯 (药代动力学、免疫学、代谢学)、Belcher(神经、分子)、Wessinger (药代动力学-)，Prather(神经，信号转导)，Mayeux(肾脏-， 代谢、信号转导)和刺激物(心血管)。教职员工 专门研究行为毒理学的人包括：麦克米兰、温格、韦辛格、 普拉瑟和欧文斯。教职员工资金充足，发展势头良好。 研究生培养实录。设施一流， 教职员工位于生物医学研究中心大楼。一股洋流和 未来国家在毒理学方面的需要是了解毒性的机制 所有级别的化学物质，从分子到行为。通过培训 在这个连续体上，调查人员将添加一池 能够满足我们国家需求的毒物学家。

DESCRIPTION (Provided by Applicant) The purpose of this proposed training program is to promote the development of toxicological sciences focusing on research in biochemical and behavioral toxicology at the University of Arkansas for Medical Sciences (UAMS) through an Institutional National Research Service Award. This will be accomplished through developing or extending the research skills and knowledge of pre-doctoral students and thereby prepare them for productive research careers. The Interdisciplinary Toxicology Graduate Program (INTOX) is a joint program between UAMS and the adjunct faculty at the National Center for Toxicological Research with students conducting their dissertation research at either institution. Also, the investigators have a Pharmacology training program (PHARM). Pre-doctoral students will be actively recruited and evaluated for admission to the graduate school on the basis of their GPA, GRE scores, letters of recommendation, and prior research experience. The pre-doctoral students will be supported by UAMS fellowships their first year. At the completion of their first year, students will be evaluated on their graduate school record, and most importantly, their performance in research rotations for participation on the training grant. The top two students will be offered support on the training grant and will be supported for years 2, 3, and 4 if they wish to specialize in biochemical and behavioral toxicology at UAMS. Their progress while on the training grant will be monitored by their participation in seminars, research and course work performance, authored manuscripts and abstracts, and annual reports. The toxicology training faculty who specialize in biochemical toxicology are: Hinson (hepato-, metabolic-, signal transduction), Schnellmann (nephro-, molecular, signal transduction), Jaeschke (hepato-, immuno-, signal transduction), Samokyszyn (metabolic-, oncology), Grant (molecular-, metabolic-), Owens (pharmacokinetic-, immuno-, metabolic-), Belcher (neuro, molecular), Wessinger (pharmacokinetic-), Prather (neuro-, signal transduction), Mayeux (nephro-, metabolic-, signal transduction), and Stimers (cardiovascular-). The faculty who specialize in behavioral toxicology include: McMillan, Wenger, Wessinger, Prather, and Owens. The faculty are well-funded and have an excellent track record of training graduate students. The facilities are excellent and the faculty are located in the Biomedical Research Center building. A current and future national need in toxicology is an understanding mechanisms of toxicity of chemicals at all levels, molecular through behavioral. By training students over this continuum the investigators will add a pool of toxicologists capable of addressing our national needs.