Hemoglobin and Blood Protein chemistry

描述(由申请人提供)： 血红蛋白和血液蛋白质化学的培训计划提供 对化学家、生化学家、生物物理学家和生物学家的培训 血蛋白、血液蛋白和循环蛋白集中在 化学研究。为提供培训而集结的教职员工 积极从事蛋白质、氧等内部电子转移的研究 与血球蛋白的结合，膜包埋蛋白的结构， 参与调节过程的蛋白质结构，细胞免疫学， 转录调控和凝血过程。他们提供以下培训： 电子自旋共振、超快动力学、X射线结晶学、原子核 磁共振光谱、荧光能量转移、蛋白质 化学，定点突变，细胞培养，基因调控， 免疫化学、基因克隆、克隆蛋白的表达；以及 血液蛋白质的调节翻译后修饰。实习生 有机会接受广泛的技术培训，因为他们 应用于生物医学研究中的特定问题。 为了提供如此多样化和多学科的方法， 这项计划是由化学系和 生物化学(10)、生物学(3)、物理学(2)、医学(2)和药理学(2)。 从历史上看，该计划的重点一直是应用 血色素和血液蛋白的生物物理化学，这解释了 化学和生物化学系做出了更大的贡献。 该项目每年资助的五名博士后实习生 根据他们在研究方面的兴趣和能力从 中国研究生项目招收的大量研究生 参与部门。每年资助的五名博士后研究员 都是根据他们以前的训练和 他们在研究能力方面的适当性 向教员个人申请加入他们的研究 程序。 培训是通过实验室研究提供的，并由 参与的教职员工，通过正式的讲座课程在参与 各部门通过定期安排的部门和小组研讨会， 并通过个人培训来使用复杂的乐器。持续时间 博士前培训的时间约为三年， 博士后培训为期一至三年，为期两年 像往常一样。

DESCRIPTION (provided by applicant): The training program in Hemoglobin and Blood Protein Chemistry provides training to chemists, biochemists, biophysicists, and biologists in hemoproteins, blood proteins, and circulating proteins concentrating on chemical studies. The faculty that has been assembled to provide the training are actively engaged in studies of electron transfer within proteins, oxygen binding to hemoproteins, the structure of membrane-embedded proteins, the structure of proteins involved in regulatory processes, cellular immunology, transcriptional regulation, and coagulation processes. They provide training in electron spin resonance, ultra fast kinetics, X-ray crystallography, nuclear magnetic resonance spectroscopy, fluorescence energy transfer, protein chemistry, site-directed mutation, cell culture, gene regulation, immunochemistry, the cloning of genes, the expression of cloned proteins; and regulatory post-translational modifications of blood proteins. The trainees have the opportunity to receive training in a wide array of techniques as they are applied to specific problems in biomedical research. In order to offer such a diverse and multidisciplinary approach, faculty for the program have been assembled from the departments of Chemistry and Biochemistry (10), Biology (3), Physics (2), Medicine (2) and Pharmacology (2). Historically, the emphasis of the program has been the application of biophysical chemistry to hemoproteins and blood proteins, which explains the larger contribution made by the Department of Chemistry and Biochemistry. The five predoctoral trainees supported each year by the program have been selected on the basis of their interests and abilities in research from among the large pool of graduate students enrolled in the graduate programs of the participating departments. The five postdoctoral fellows supported each year have been selected on the basis of their former training and the appropriateness of their abilities in research from among candidates who have applied to the individual members of the faculty to join their research programs. Training is provided through laboratory research under the direction of the participating faculty, through formal lecture courses in the participating departments, through regularly scheduled departmental and small group seminars, and through individual training in the use of complex instruments. The duration of the predoctoral training is about three years and the duration of the postdoctoral training is from one to three years with a two-year period being usual.