Exploring the role of the anti-ageing molecule sirtuin-1 in cellular senescence in primary human lung cells

该项目将研究肺细胞衰老的机制。Sirtuin-1 （SIRT-1）是一种关键的抗衰老分子，在慢性阻塞性肺疾病（COPD）、心血管疾病和2型糖尿病等几种加速衰老的慢性疾病中减少。它将使用各种工具试剂进一步探索SIRT1在细胞衰老中的作用。这些包括mTOR及其下游激酶p70S6K的新抑制剂，AMP激酶的激活剂，阻断miR-34a和-570的新型拮抗剂以及修复SIRT-1表达的修饰mRNA。

The project will study the mechanism of cellular senescence in the lung. Sirtuin-1 (SIRT-1), a key anti-ageing molecule, is reduced in several chronic diseases of accelerated ageing, including chronic obstructive pulmonary disease (COPD), cardiovascular diseases and type 2 diabetes. It will explore further the role of SIRT1 in cellular senescence using a variety of tool reagents. These include new inhibitors of mTOR and its downstream kinase p70S6K, activators of AMP kinase, novel antagomirs to block miR-34a and -570 and modified mRNA to restore SIRT-1 expression.