Translation of novel polymer anti-bacterial coating to invasive medical devices used in the neonatal intensive care for high risk preterm infants

早产儿感染是导致死亡和严重疾病的主要原因，并与幸存者的长期预后不良有关。重症监护病房的早产儿在住院期间通常通过其维持生命的医疗设备获得这些感染。这个学生将为这些设备开发新的涂层，以抵抗细菌定植，从而降低这些脆弱婴儿的感染风险。该学生将在世界领先的诺丁汉大学药学院与医学院的新生儿学者合作，开发新的涂层，并与我们的工业合作伙伴密切合作，在体外和体内进行测试。将有机会在哈维尔研究中心接受培训，学习尖端技能，并在医院环境中，在大型研究活跃的新生儿重症监护病房中度过时间，以更好地了解临床需求。这个博士学位将适合一个雄心勃勃的科学毕业生，在生物学或化学领域，谁希望承担一个真正的转化临床项目与行业合作和培训。预计在项目结束时，该学生将很好地为临床试验和正在进行的开发或商业化获得后续资金。

Infections in premature babies are a leading cause of death, severe illness and are associated with poor long-term outcomes for survivors. Premature babies on intensive care units acquire these infections whilst in hospital, often from their life-supporting medical devices. This studentship will develop new coatings for these devices that resist bacterial colonisation and so reduce the risk of infection in these vulnerable babies. Based in the world-leading School of Pharmacy at the University of Nottingham, in partnership with academic neonatologists in the School of Medicine, the student will develop the new coatings, test them in vitro and in vivo, working closely with our industrial collaborator. There will be opportunities to train at the Harwell Research Complex learning cutting edge skills and spend time in the hospital environment, in a large research-active neonatal intensive care unit, to better understand the clinical need. This PhD will suit a highly ambitious science graduate, in the field of biology or chemistry, who wishes to undertake a truly translational clinical project with industry collaboration and training. It is expected that at the end of the project, the student will be well placed to secure follow-on funding for clinical trials and on-going development or commercialisation.