How is an important immune regulatory protein controlled?

一种名为吲哚胺2，3-双加氧酶的酶在正常和疾病情况下(包括怀孕、癌症、炎症和传染病)对控制免疫系统非常重要。尽管它很重要，但人们对这种酶是如何控制的知之甚少。这个项目将为这种酶是如何调节的提供重要的新见解。这些基本的科学信息可以发现改变酶活性以调节免疫反应的新方法。

An enzyme called indoleamine 2,3-dioxygenase is important for controlling the immune system during normal and disease conditions including pregnancy, cancer, inflammation and infectious disease. Despite its importance little is known about how this enzyme is controlled. This project will provide important new insights into how this enzyme is regulated. Such fundamental scientific information can discover new ways in which to alter the enzyme's activity in order to modulate immune responses.