Novel Blood Oxygenator Homogeneous Membranes

描述（由申请人提供）： 长期血液氧合器（BO）治疗需要无孔膜来限制BO浸湿。紧凑型膜系统（CMS）已经确定了（1）可以使润湿最小化（同时保持气体的所需气-液输送）的新型材料和（2）将这些材料制成BO的新型制造技术。 在第一阶段计划中，CMS将联合收割机将这些新材料与新的制造技术相结合，以展示增强BO的可行性。我们将分析系统相比，现有的BO控制的整体氧传质和长期稳定性。 体外试验将提供关键性能和生物相容性数据。平行体内研究（在其他项目中成功完成）将提供有关系统功能的关键附加信息。虽然CMS相信新的制造技术可以应用于新材料，但如果原始工艺不起作用，我们也确定了平行的制造路线。

DESCRIPTION (provided by applicant): Long-term blood oxygenators (BO) therapy requires non-porous membranes to limit BO wet out. Compact Membrane Systems (CMS) has identified (1) novel materials that can minimize wet out (while simultaneously maintaining needed gas-liquid transport of gases) and (2) a novel fabrication technique to make these materials into BO. In this Phase I program, CMS will combine these novel materials with novel fabrication technique to show the feasibility of an enhanced BO. We will analyze the system compared to existing BO controls for overall oxygen mass transfer and long-term stability. In-vitro testing will provide key performance and biocompatibility data. Parallel in-vivo studies (successfully completed in other programs) will provide key additional information on system capabilities. While CMS is confident that the novel fabrication technique can be applied to the novel materials, we have also identified parallel fabrication routes if the original process does not work.