Hepatitis B & Liver Cancer Prevention in Asian Americans

描述（由申请人提供）：该健康保护研究计划指导研究科学家发展奖（K01）将为候选人John H. Choe提供多学科工具，使其成为一名独立研究者，特别关注亚洲移民人群的乙型肝炎（HBV）和肝癌控制。为此，崔博士有几个相关的职业目标，将通过拟议的教学课程、临床培训和指导研究活动来实现。这些包括：(1)通过在弱势群体中担任受指导的首席研究员来扩大他的癌症控制研究经验；(2)有助于了解不同亚洲人群在疾病预防和癌症控制方面的异同；(3)通过检验亚裔美国人自我报告健康行为的效度，推进亚裔美国人癌症控制和疾病预防的研究方法；(4)提交关于韩裔美国人预防乙型肝炎和肝癌的R01资助申请。

DESCRIPTION (provided by applicant): This Health Protection Research Initiative Mentored Research Scientist Development Award (K01) will provide the candidate, John H. Choe, the multidisciplinary tools to become an independent investigator with special focus on hepatitis B (HBV) and liver cancer control in Asian immigrant populations. Toward this end, Dr. Choe has several related career goals that will be achieved through proposed didactic coursework, clinical training, and mentored research activities. These include: (1) To expand his cancer control research experience by serving as the mentored principal investigator in a vulnerable population; (2) To contribute to the understanding of similarities and differences of disease prevention and cancer control across different Asian populations; (3) To advance cancer control and disease prevention research methodology in Asian Americans by testing the validity of self-reported health behavior; and (4) To submit an R01 grant application addressing hepatitis B and liver cancer prevention in Korean Americans. Largely attributable to high rates of chronic HBV infection and low rates of vaccination, hepatocellular carcinoma (primary liver cancer) affects Asians more than other populations in the US. The proposed research activity would examine rates of HBV and liver cancer testing and vaccination, as well as associations with sociodemographic and other factors, among Korean Americans in Washington State; survey results from Korean Americans will then be compared with those collected previously from the Chinese American community. The research activities proposed for Dr. Choe during this mentored research career development award are: . To develop a culturally-appropriate survey instrument of HBV and liver cancer practices for Korean Americans, incorporating results from a qualitative pilot study and Bastani's Health Behavior Framework. . Using this questionnaire, to identify sociodemographic and other factors associated with recommended HBV testing among 600 ethnic Koreans from the metropolitan area of Tacoma, Washington. . To compare the similarities and differences of factors associated with recommended HBV testing across two Asian American populations: Koreans and Chinese . To conduct a supplemental analysis of the validity of self-reported HBV testing behavior by reviewing a subset of survey participant medical records among Korean and Chinese Americans. . To develop and pre-test a hepatitis B educational intervention for Korean Americans; this will provide feasibility and acceptability information for an intended R01 grant application to address liver cancer in this population.