EARLY CARIES DETECTION AND INTERVENTION

这个多地点项目资助申请（PO1）的标题是“早期龋齿检测和干预”。本P01的目标之一是确定各种诊断技术测量牙釉质脱矿早期变化的能力。目前可用的技术包括定量光荧光（QLF）、红外激光荧光（IR）和电导率（EC）。有一个巨大的需要验证所有新的临床检测方法的应用，无论是原发性和继发性龋。它已经表明，“早期护理病变的诊断可以被视为具有成本效益的卫生保健服务和质量的牙科保健的基石。”（美国牙医学会龋齿诊断研讨会）。三个项目将用于验证这些新诊断技术的使用，然后将这些技术应用于原发性龋齿（印第安纳州，项目3）和继发性龋齿（德克萨斯州/印第安纳州，项目2）的临床试验。这些干预措施将首先在项目1中进行有效性测试，如果可以接受，将其用作初级和/或二级临床龋齿试验的干预措施。在试验期间脱落的牙齿将在爱荷华州进行分析，使用偏振光显微镜作为“金标准”，以确定病变形成的存在和/或程度。项目之间的相互关系和研究目标的互补性质将产生协同作用，远远超过单个项目在单个地点的作用。这一系列的研究预计将：1)验证新的成像技术，在比目前可能的更早的发展阶段检测原发性和继发性龋齿；2)采用合适的体外和原位模型确定最有效的干预方法；3)利用这些早期龋病检测方法监测原发性和继发性龋病的临床有效干预措施。行政核心和生物统计核心将支持这些项目。项目主任将接受内部指导委员会和外部咨询委员会的建议和审查。三所研究型大学的合作努力，长期的专业知识和多样化的人口为P01提供了独特的资源组合。

The title for this multi-site program grant application (PO1) is "Early Caries Detection and Intervention." One of the goals of this P01 is to determine the ability of various diagnostic techniques to measure early changes in enamel demineralization. Currently available techniques include quantitative light fluorescence (QLF), infrared laser fluorescence (IR), and electrical conductivity (EC). There is a tremendous need to validate the application of all new developing clinical detection methods, both for primary and secondary caries. It has been stated that "The Diagnosis of early care lesions can be regarded as the cornerstone of cost- effective health care delivery and quality of dental care." (ORCA Symposium on Caries Diagnosis). Three projects will be used to validate the use of these newer diagnostic techniques and then apply those techniques in clinical trials of both primary (Indiana, Proj. 3) and secondary caries (Texas/Indiana, Proj. 2). The interventions will first be tested in Project 1 for effectiveness and if acceptable used as an intervention for primary and/or secondary clinical caries trials. Teeth that are exfoliated during the trials will be analyzed at Iowa for the presence and/or extent of lesion formation using polarized light microscopy as the "gold standard" The interrelationships between the projects and complimentary nature of the research objectives will produce a synergism that offers far more than merely individual projects at individual sites. These series of studies are expected to: 1) Validate new imaging technologies for the detection of both primary and secondary dental caries at a much earlier stage of development than is currently possible; 2) Determine the most effective intervention methods using the appropriate in vitro and in situ models; 3) Use these early caries detection methods to monitor clinically effective interventions for primary and secondary caries. An Administrative Core and a Biostatistics Core will support the projects. The project director will receive advice and review from both an internal Steering Committee and External Advisory Committee. The collaborative efforts of the three research-intensive Universities, the long- standing expertise and diverse populations offer a unique combination of resources for this P01.