Design, development and testing of novel inflammation resolving stimuli-responsive nanogels

纳米凝胶是由交联多孔聚合物网络组成的纳米范围内的水凝胶，具有在保持其结构的同时保留大量水或生物流体的能力。它们在设计上具有广泛的灵活性，允许通过选择单体构建块轻松调整其特性，如尺寸，电荷，孔隙度和可降解性。因为纳米凝胶可以保留大量的水，所以它们具有极强的生物相容性。这种优异而独特的特性使它们成为递送生物药物（如酶和蛋白质）的理想纳米平台。为此，该项目将专注于刺激反应纳米凝胶的开发，这种纳米凝胶可以提供高效的先天生物有效载荷，如消炎蛋白、肽和核酸

Nanogels are hydrogels within the nanometer range consisting of cross-linked porous polymer networks with the ability to retain high volumes of water or biological fluids while maintaining their structure. They have a wide range of flexibility in their design, allowing their characteristics such as size, charge, degree of porosity, and degradability to be easily tuned by the choice of monomeric building blocks. Because nanogels can retain a high volume of water, they are extremely biocompatible. This excellent and unique property makes them an ideal nanoplatform for the delivery of biological drugs, such as enzymes and proteins. To this end, this project will focus on the development of stimuli-responsive nanogels that can deliver highly potent innate biological payloads such inflammation resolving proteins, peptides and also nucleic acids