Does Tel2p act DNA double-strand breaks?

描述(申请人提供)：这个项目的总体目标是应用生物信息学和遗传学方法来研究以酿酒酵母为模型系统的寿命控制。具体地说，这项研究将使用多个长寿和短寿突变的转录图谱来识别有丝分裂和有丝分裂后衰老所需的基因。识别出的基因将根据与改变的寿命相关的表型以及它们对正常寿命的需求而被分组到遗传途径中。将使用生物信息学工具确定寿命控制途径的调控成分，以确定具有统计意义的过度代表的功能相关基因和序列元件组，这些基因和序列元件可能调节其转录。这些研究的结果将为理解所有模式生物的寿命控制机制提供一个有价值的模式系统。

DESCRIPTION (provided by applicant): The overall goal of this project is to apply bioinformatic and genetic approaches to study the control of life span using Saccharomyces cerevisiae as a model system. Specifically, this study will use transcriptional profiling of multiple long-lived and short-lived mutants to identify genes required for mitotic and post-mitotic aging. The genes identified will be grouped into genetic pathways based on phenotypes associated with altered life span as well as their requirement for normal life span. Regulatory components of the life span controlling pathways will be identified using bioinformatics tools to determine statistically significant over-represented groups of functionally related genes and sequence elements that may regulate their transcription. The results from these studies will provide a valuable model system for understanding the mechanism of life span control in all model organisms.