Interstitial Cystitis Clinical Research Network (ICCRN)

描述（由申请人提供）： 本提案的长期目标和具体目标是将爱荷华州大学间质性膀胱炎研究组建立为间质性膀胱炎临床研究网络（ICCRN）的临床中心。 该网络的目的是建立一个具有盆腔疼痛和间质性膀胱炎专业知识的中心协作组，以进行对照临床试验，从而进一步了解间质性膀胱炎。此外，该网络将参加泌尿科慢性盆腔疼痛Syndrome协作组进行慢性前列腺炎的试验。 一个使用低剂量卡介苗和干扰素α（α）的概念协议包括在这个建议。 以下章节中概述的招募、营销和保留策略将确保每月招募4至6名患者，并最大限度地提高该中心招募少数群体的能力。该中心拥有方案中规定的所有临床和实验室支持。 以下章节概述了招募男性和女性间质性膀胱炎患者的创新方法以及确保长期依从性和完成所有计划随访访视的多种策略。 总之，本提案概述了我们认为爱荷华州大学间质性膀胱炎研究组作为多机构间质性膀胱炎临床研究网络（ICCRN）临床中心的杰出资质。

DESCRIPTION (provided by applicant): The long-term objectives and specific aims of this proposal are to establish the University of Iowa Interstitial Cystitis Research Group as a clinical center in the Interstitial Cystitis Clinical Research Network (ICCRN). The purpose of this network is to establish a collaborative group of centers with expertise in pelvic pain and interstitial cystitis to conduct controlled clinical trials that will provide further understanding of interstitial cystitis. Additionally this network will participate in the Urologic-Chronic Pelvic Pain Syndromes Collaborative Group to conduct trials in chronic prostatitis. A concept protocol using low dose BCG and interferon-alpha(alpha) is included in this proposal. The recruitment, marketing and retention strategies outlined in the following sections will ensure enrollment of between four and six patients per month as well as maximize this center's ability to recruit minority populations. This center has all the clinical and laboratory support as stated in the protocol. The following sections outline innovative methods to recruit both male and female interstitial cystitis patients as well as multiple strategies to ensure long term compliance and completion of all scheduled follow-up visits. In summary, this proposal outlines what we believe are the outstanding credentials of the University of Iowa Interstitial Cystitis Research Group to serve as a Clinical Center in the multi-institutional Interstitial Cystitis Clinical Research Network (ICCRN).