Multi-disciplinary Approach to the Study of Chronic Pelvic Pain (MAPP)

慢性盆腔疼痛 (MAPP) 研究的多学科方法

• 批准号: 7901945
• 负责人: Karl J Kreder
• 金额: $ 19.8万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-27 至 2011-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7901945
• 关键词: Multi; disciplinary; Approach; Study; Chronic

DESCRIPTION, OVERALL (provided by applicant): Despite years of research and a considerable monetary expenditure the pathophysiology of the Urologic Chronic Pelvic Pain Syndrome (UCPPS) known as Interstitial Cystitis/Painful Bladder Syndrome (IC/PBS) remains elusive. This University of Iowa MAPP grant proposal is intended to study this condition from a new perspective. The proposal is designed around the general hypothesis that patients with IC/PBS bladder symptoms and a co-morbid condition like fibromyalgia (FM) or irritable bowel syndrome (IBS) have systemic basis for their symptoms and are fundamentally different from patients with IC/PBS bladder symptoms alone. We based our general hypothesis on the previous work of the investigators in this MAPP application which is detailed in subsequent sections. During the program project planning and design phase for the 5 projects proposed in this grant, all investigators worked from this general hypothesis. The proposed work is important because of its novel nature and the synergy and horizontal integration among the 5 proposed projects. The projects were planned to examine the heterogenous condition of IC/PBS. The cohorts of patients to be studied are similar across all clinical projects and include patients with IC/PBS symptoms in the bladder only, patients with IC/PBS bladder symptoms and a systemic co-morbid condition (FM, IBS), patients with only a co-morbid condition (FM.IBS) and healthy controls. The basic science projects reinforce and expand the scope of the clinical projects by utilizing biologic specimens collected in the clinical projects to add basic cellular, molecular and biochemical understanding of the UCPPS syndrome (IC/PBS). The Project proposals examine the UCPPS of IC/PBS from a multifaceted perspective. Subsequent data analysis of this Discovery Site project will describe the phenotype and risk factors of each group related to the HPA axis, stress response, neurophysiology, pain pattern, biologic and behavioral predisposing factors, basic immunology and biochemistry.

总体描述（由申请人提供）：尽管经过多年的研究和大量的资金支出，泌尿系统慢性盆腔疼痛综合征（UCPPS）（称为间质性膀胱炎/膀胱疼痛综合征（IC/PBS））的病理生理学仍然难以捉摸。爱荷华大学 MAPP 拨款提案旨在从新的角度研究这种情况。该提案围绕这样一个一般假设而设计，即患有 IC/PBS 膀胱症状和纤维肌痛 (FM) 或肠易激综合征 (IBS) 等共病的患者其症状具有系统基础，并且与仅患有 IC/PBS 膀胱症状的患者有根本不同。我们的一般假设基于研究人员之前在此 MAPP 应用程序中的工作，后续部分将详细介绍。在本次拨款中提出的 5 个项目的项目规划和设计阶段，所有研究人员都根据这一一般假设开展工作。拟议的工作因其新颖性以及 5 个拟议项目之间的协同作用和横向整合而非常重要。这些项目计划检查 IC/PBS 的异质条件。所有临床项目中待研究的患者群体都是相似的，包括仅膀胱出现 IC/PBS 症状的患者、具有 IC/PBS 膀胱症状和全身共病 (FM、IBS) 的患者、仅患有共病 (FM.IBS) 的患者和健康对照。基础科学项目通过利用临床项目中收集的生物标本来加强和扩大临床项目的范围，以增加对 UCPPS 综合征 (IC/PBS) 的基本细胞、分子和生化理解。项目提案从多方面的角度审视了 IC/PBS 的 UCPPS。该发现站点项目的后续数据分析将描述与 HPA 轴、应激反应、神经生理学、疼痛模式、生物和行为诱发因素、基础免疫学和生物化学相关的每组的表型和危险因素。