Urology Chronic Pelvic Pain Longitudinal Symptom Patterns Study

泌尿科慢性盆腔疼痛纵向症状模式研究

• 批准号: 10206103
• 负责人: Karl J Kreder
• 金额: $ 14.58万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10206103
• 关键词: Biological; Chronic; Chronic Fatigue Syndrome; Chronic Prostatitis; Clinical; Clinical Research; Clinical Trials Design; Data; Data Analyses; Enrollment; Epidemiology; Etiology; Event; Fibromyalgia; Funding; Goals; Individual; Interstitial Cystitis; Iowa; Irritable Bowel Syndrome; Manuscripts; Measurement; Measures; Michigan; National Institute of Diabetes and Digestive and Kidney Diseases; Natural History; Pain; Pain Disorder; Participant; Pattern; Persons; Phase; Phenotype; Physiological; Preparation; Protocols documentation; Research; Research Personnel; Risk Factors; Site; Symptoms; System; Time; Universities; Urology; Washington; Woman; chronic painful condition; chronic pelvic pain; clinically relevant; design; epidemiologic data; follow-up; improved; insight; interdisciplinary approach; men; participant enrollment; patient subsets; recruit; response; symptom management; treatment response; trend; urologic; urologic chronic pelvic pain syndrome

PROJECT SUMMARY/ABSTRACT Urologic Chronic Pelvic Pain Syndrome (UCPPS) encompasses two highly prevalent chronic urologic pain disorders, interstitial cystitis/ bladder pain syndrome (IC/BPS) in men and women, and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men. Like many chronic pain disorders, UCPPS is poorly understood and characterized, and treatment is mostly empirical and unsatisfactory. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was established by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), to study the etiology and treated natural history of UCPPS, to inform better treatments and management of symptoms through improved designs of clinical trials, and to identify clinical factors and research measurements to define clinically relevant sub-groups of these patients. The MAPP Research Network is currently completing enrollment of participants into the Trans-MAPP Symptom Patterns Study (SPS), which involves integrated phenotyping of UCPPS participants at baseline and during a 36-month longitudinal, observational period. The SPS includes measures to refine UCPPS subgrouping, identify symptom trends, and discover associated risk factors and biological correlates to progression profiles. Integrated within the central protocol are studies to correlate clinical and biological profiles with response to selected UCPPS therapies (the Analysis of Therapies during Longitudinal Assessment of Symptoms [ATLAS] study). The current funding period ends in June 2019. We propose a three-year funding extension, through June 2022. During the proposed three-year extension, we aim to accomplish the following: SPECIFIC AIM 1: To Obtain an Additional 12 Months of Follow-up in the MAPP-II SPS. The MAPP-II SPS was designed to follow UCPPS participants for up to three years. By extending the timeframe for longitudinal follow-up from July 2019 to July 2020, the number of UCPPS participants followed for three years in the SPS will almost double (from 198 to 384). This additional data will substantially increase the ability of MAPP investigators to examine patterns and predictors of UCPPS symptoms over time. SPECIFIC AIM 2: To Observe Additional ATLAS Events in the MAPP-II SPS. A major focus of the MAPP-II SPS is to correlate individual participant phenotypes with UCPPS treatment response. To accomplish this, SPS participants complete a phenotyping assessment before and after starting new UCPPS treatments (ATLAS study). The additional year of follow-up will provide time for new treatment `events' to occur which can be included in this important analysis. SPECIFIC AIM 3: To Conduct Analyses of MAPP-II Data. The current funding period provides inadequate time for MAPP investigators to analyze the data collected as part of the SPS. Therefore, the final two years of the proposed three-year MAPP-II extension will be devoted exclusively to data analysis and manuscript preparation.

项目总结/文摘

项目成果

Sub-noxious Intravesical Lipopolysaccharide Triggers Bladder Inflammation and Symptom Onset in A Transgenic Autoimmune Cystitis Model: A MAPP Network Animal Study.

• DOI: 10.1038/s41598-018-24833-x
• 发表时间: 2018-04-26
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Kogan P;Xu S;Wang Y;O'Donnell MA;Lutgendorf SK;Bradley CS;Schrepf A;Kreder KJ;Luo Y
• 通讯作者: Luo Y

Assessment of the Lower Urinary Tract Microbiota during Symptom Flare in Women with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study.

泌尿科慢性盆腔疼痛综合征女性症状发作期间下尿路微生物群的评估：MAPP 网络研究。

• DOI: 10.1016/j.juro.2015.09.075
• 发表时间: 2016-02
• 期刊: The Journal of urology
• 作者: Nickel JC;Stephens A;Landis JR;Mullins C;van Bokhoven A;Lucia MS;Ehrlich GD;MAPP Research Network
• 通讯作者: MAPP Research Network

Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics.

• DOI: 10.1016/j.biopsych.2011.10.007
• 发表时间: 2012-02-15
• 期刊: BIOLOGICAL PSYCHIATRY
• 影响因子: 10.6
• 作者: Antoni, Michael H.;Lutgendorf, Susan K.;Blomberg, Bonnie;Carver, Charles S.;Lechner, Suzanne;Diaz, Alain;Stagl, Jamie;Arevalo, Jesusa M. G.;Cole, Steven W.
• 通讯作者: Cole, Steven W.

Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network.

泌尿科慢性盆腔疼痛综合征症状发作期间症状的变化：来自 MAPP 研究网络一个站点的发现。

• DOI: 10.1002/nau.22534
• 发表时间: 2015
• 期刊: Neurourology and urodynamics
• 影响因子: 2
• 作者: Sutcliffe,Siobhan;Colditz,GrahamA;Pakpahan,Ratna;Bradley,CatherineS;Goodman,MelodyS;Andriole,GeraldL;Lai,HHenry
• 通讯作者: Lai,HHenry

Search for Microorganisms in Men with Urologic Chronic Pelvic Pain Syndrome: A Culture-Independent Analysis in the MAPP Research Network.

• DOI: 10.1016/j.juro.2015.01.037
• 发表时间: 2015-07
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: Nickel, J. Curtis;Stephens, Alisa;Landis, J. Richard;Chen, Jun;Mullins, Chris;van Bokhoven, Adrie;Lucia, M. Scott;Melton-Kreft, Rachael;Ehrlichk, Garth D.
• 通讯作者: Ehrlichk, Garth D.