CORE--PATIENT CARE AND TECHNICAL SUPPORT

描述（由申请人提供）：核心B的主要职责是 提供将在四项研究中研究的患者人群， 项目，并为所有人提供技术和统计支持， investigators.这四个研究项目高度相互依存， 相互关联每个项目都依赖于 其他项目，以回答在其具体的研究问题， 目标。他们还使用相同的患者人群来解决以下总体目标： 临床研究中心以及每个项目的具体目标。这 第节将描述受试者招募的广泛术前评价， 具体人群进行研究，人工耳蜗植入期间使用 研究方案，以及总体研究设计和时间的一般方法- 受试者参与线。总体统计设计、数据管理和 讨论了技术支持。对具体研究的描述 问题以及每个项目如何相互作用和依赖于其他项目 在个别项目中提出。

DESCRIPTION (provided by applicant): The primary responsibilities of Core B are to provide the patient population that will be studied in the four research projects and to establish the technical and statistical support for all investigators. The four research projects are highly interdependent and interrelated. Each project depends on the questions and data generated by the other projects to answer the research questions addressed in their specific aims. They also use the same patient populations to address the overall goals of the Clinical Research Center as well as the specific aims of each project. This section will describe the extensive preoperative evaluation for subject accrual, specific populations to be studied, the cochlear implants to be used during the research protocol, and the general methods of the overall study design and time- line of subject involvement. The overall statistical design, data management and technical support are discussed. A description of the specific research questions and how each project is interactive and dependent on other projects are presented in the individual projects.