How does bronchoconstriction worsen asthma?

哮喘通过气道狭窄引起喘息和呼吸急促，哮喘发作通常由病毒感染引起。我们计划研究哮喘发作期间气道狭窄如何降低身体抵抗病毒感染的能力，导致长期感染，哮喘症状恶化，更多的气道炎症和气道内的长期损伤。我们将尝试使用现有的和新的治疗方法来扭转这些问题，并改善哮喘的治疗。

Asthma causes wheeze and shortness of breath via airway narrowing, with asthma attacks commonly caused by virus infections. We plan to investigate how airway narrowing during an asthma attack decreases the body’s ability to fight off a viral infection, causing prolonged infection, worse asthma symptoms, more airway inflammation and long-term damage within the airways. We will attempt to use current and novel treatments to reverse these problems, and improve treatment for asthma.